3-(1H-咪唑-4-基)-丙酸乙酯合成路线 （共 10 条）
反应条件
1: LiAlH4 / tetrahydrofuran / 15 h / 20 °C 2: triethylamine / dimethylformamide / 2 h / 20 °C View Scheme
参考文献
Wijtmans, Maikel; De Graaf, Chris; De Kloe, Gerdien; Istyastono, Enade P.; Smit, Judith; Lim, Herman; Boonnak, Ratchanok; Nijmeijer, Saskia; Smits, Rogier A.; Jongejan, Aldo; Zuiderveld, Obbe; De Esch, Iwan J. P.; Leurs, Rob
Journal of Medicinal Chemistry, 2011 , vol. 54, # 6 p. 1693 - 1703
反应条件
1: 82.4 percent / 1 M NaHCO3 / ethyl acetate
2: 50 mg / 1 M HCl / ethanol / 48 h / Heating
View Scheme
参考文献
Altman, Janina; Shoef, Nurit; Wilchek, Meir; Warshawsky, Abraham
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 1 p. 59 - 62
反应条件
sodium hydrogencarbonate in ethyl acetate
参考文献
Altman, Janina; Shoef, Nurit; Wilchek, Meir; Warshawsky, Abraham
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 1 p. 59 - 62
反应条件
sodium hydrogencarbonate in ethyl acetate
Ambient temperature;
参考文献
Altman, Janina; Shoef, Nurit; Wilchek, Meir; Warshawsky, Abraham
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 1 p. 59 - 62
反应条件
1: 82.4 percent / 1 M NaHCO3 / ethyl acetate
2: 95 percent / hydrogen / 10percent Pd-C / ethanol / 20 h / 50 °C / Parr apparatus
View Scheme
参考文献
Altman, Janina; Shoef, Nurit; Wilchek, Meir; Warshawsky, Abraham
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 1 p. 59 - 62
反应条件
1: 82.4 percent / 1 M NaHCO3 / ethyl acetate
2: 95 percent / hydrogen / 10percent Pd-C / ethanol / 20 h / 50 °C / Parr apparatus
3: 88 percent / 36percent hydrochloric acid / acetic acid / 24 h / Heating
View Scheme
参考文献
Altman, Janina; Shoef, Nurit; Wilchek, Meir; Warshawsky, Abraham
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 1 p. 59 - 62
反应条件
1: 82.4 percent / 1 M NaHCO3 / ethyl acetate
2: 95 percent / hydrogen / 10percent Pd-C / ethanol / 20 h / 50 °C / Parr apparatus
3: 73.5 percent / 1 M KOH / methanol / 24 h / Ambient temperature
View Scheme
参考文献
Altman, Janina; Shoef, Nurit; Wilchek, Meir; Warshawsky, Abraham
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 1 p. 59 - 62
反应条件
1: 82.4 percent / 1 M NaHCO3 / ethyl acetate
2: 95 percent / hydrogen / 10percent Pd-C / ethanol / 20 h / 50 °C / Parr apparatus
3: 88 percent / 36percent hydrochloric acid / acetic acid / 24 h / Heating
4: 51 percent / aq. KOH / H2O / 50 °C / 1.) pH 9.5-10, 9 h, 2.) pH 11, overnight
View Scheme
参考文献
Altman, Janina; Shoef, Nurit; Wilchek, Meir; Warshawsky, Abraham
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 1 p. 59 - 62
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; Inert atmosphereCooling with ice;
参考文献
Wijtmans, Maikel; De Graaf, Chris; De Kloe, Gerdien; Istyastono, Enade P.; Smit, Judith; Lim, Herman; Boonnak, Ratchanok; Nijmeijer, Saskia; Smits, Rogier A.; Jongejan, Aldo; Zuiderveld, Obbe; De Esch, Iwan J. P.; Leurs, Rob
Journal of Medicinal Chemistry, 2011 , vol. 54, # 6 p. 1693 - 1703
反应条件
sodium hydroxide; lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Merck and Co., Inc.
Patent: US5856326 A1, 1999 ;
US 5856326 A
