6-(噻吩-2-基)-4,5-二氢吡嗪-3(2H)-酮合成路线 （共 7 条）
反应条件
1: 83 percent / O2NC6H4SO3Na-m, NaOH / H2O; ethanol / 2 h / 100 °C
2: 68 percent / POCl3 / 1.5 h / 135 °C
3: 85 percent / N2H4*H2O / 3 h / Heating
View Scheme
参考文献
Steiner; Gries; Lenke
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 59 - 63
反应条件
1: 87 percent / Br2 / acetic acid / 3 h / 70 °C
2: oxychlorure de phosphore
3: 86 percent / hydrazine (50 percent) / ethanol / 1 h / Heating
View Scheme
参考文献
Bourguignon, Jean; Becue, Christian; Queguiner, Guy
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 425 - 427
反应条件
1: 87 percent / Br2 / acetic acid / 3 h / 70 °C
2: oxychlorure de phosphore
3: 86 percent / hydrazine (50 percent) / ethanol / 1 h / Heating
4: 53 percent / aq. acide hydrochlorique, nitrite de sodium / acetic acid
View Scheme
参考文献
Bourguignon, Jean; Becue, Christian; Queguiner, Guy
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 425 - 427
反应条件
sodium hydroxide; m-nitrobenzene sulfonic acid sodium salt in ethanol; water
T=100°C; 2 h;
参考文献
Steiner; Gries; Lenke
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 59 - 63
反应条件
sodium hydroxide in water; acetic acid
参考文献
American Cyanamid Company
Patent: US4260756 A1, 1981 ;
反应条件
hydrazine hydrate in ethanol
7 h; Heating;
参考文献
Steiner; Gries; Lenke
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 59 - 63
反应条件
sodium acetate; hydrazine hydrate in methanol
condensation; Heating;
参考文献
Khan; Siddiqui
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000 , vol. 39, # 8 p. 614 - 619
