4-(6-氧代-1,6-二氢吡嗪-3-基)苯甲腈合成路线 （共 4 条）
反应条件
in water; trichlorophosphate
参考文献
American Cyanamid Company
Patent: US4092311 A1, 1978 ;
反应条件
pyridine; oxygen; copper diacetate; sodium carbonate in toluene
T=20 - 100°C; 12 h; chemoselective reaction;
参考文献
Liang, Lei; Yang, Guanyu; Xu, Fengrong; Niu, Yan; Sun, Qi; Xu, Ping
European Journal of Organic Chemistry, 2013 , # 27 p. 6130 - 6136
反应条件
1: With acetic acid
T=95 - 100°C;
2: With ammonia
ice-cooling;
3: With NH2NH2•xH2O
3 h; Reflux;
参考文献
MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
Patent: US2010/179148 A1, 2010 ;
Location in patent: Page/Page column 20-21 ;
反应条件
ethylenediamine in N-methyl-acetamide; water
参考文献
American Cyanamid Company
Patent: US4092311 A1, 1978 ;
