4-(4-甲氧苯基)-1-丁醇合成路线 （共 34 条）
参考文献
Mohamed, Salah E.N.; Whiting, Donald A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 10 p. 2577 - 2582
反应条件
1: 94 percent / pyridine
2: 91 percent / LiBr / acetone
3: 71 percent / Na, EtOH / 1.5 h / Heating
View Scheme
参考文献
Mohamed, Salah E.N.; Whiting, Donald A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 10 p. 2577 - 2582
反应条件
1: 94 percent / pyridine
2: 91 percent / LiBr / acetone
3: 71 percent / Na, EtOH / 1.5 h / Heating
4: 58 percent / m-chloroperbenzoic acid / CH2Cl2 / 6 h
View Scheme
参考文献
Mohamed, Salah E.N.; Whiting, Donald A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 10 p. 2577 - 2582
反应条件
DCN in acetonitrile
T=20°C; 3 h; Inert atmosphereIrradiation;
参考文献
Pandey, Ganesh; Pal, Sujit; Laha, Ramkrishna
Angewandte Chemie - International Edition, 2013 , vol. 52, # 19 p. 5146 - 5149
Angew. Chem., 2013 , vol. 125, # 19 p. 5250 - 5253,4
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in 1,4-dioxane
Ambient temperature;
参考文献
Harwood, Laurence M.; Robertson, Jeremy
Tetrahedron Letters, 1987 , vol. 28, # 43 p. 5175 - 5176
反应条件
1: SOCl2 / tetrahydrofuran / 2 h / 50 °C
2: KI / dimethylformamide / 12 h / Heating
3: BBr3 / CH2Cl2 / 3.5 h / -78 - 20 °C
View Scheme
参考文献
Apelt, Joachim; Ligneau, Xavier; Pertz, Heinz H.; Arrang, Jean-Michel; Ganellin, C. Robin; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger
Journal of Medicinal Chemistry, 2002 , vol. 45, # 5 p. 1128 - 1141
反应条件
1: PBr3
2: BBr3 / CH2Cl2
View Scheme
参考文献
Tamiz, Amir P.; Whittemore, Edward R.; Woodward, Richard M.; Upasani, Ravindra B.; Keana, John F.W.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1619 - 1624
反应条件
1: pyridine / tetrahydrofuran / 20 °C
2: sodium azide / dimethylformamide / 20 °C
3: 94 percent / Ph3P; H2O / tetrahydrofuran / 20 °C
4: 90 percent / aq. HBr / 3 h / Heating
5: 62 percent / sodium bicarbonate / dioxane; H2O / -2 - 20 °C
View Scheme
参考文献
Hirsh, Andrew J.; Molino, Bruce F.; Zhang, Jianzhong; Astakhova, Nadezhda; Geiss, William B.; Sargent, Bruce J.; Swenson, Brian D.; Usyatinsky, Alexander; Wyle, Michael J.; Boucher, Richard C.; Smith, Rick T.; Zamurs, Andra; Johnson, M. Ross
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4098 - 4115
反应条件
1: pyridine / tetrahydrofuran / 20 °C
2: sodium azide / dimethylformamide / 20 °C
3: 94 percent / Ph3P; H2O / tetrahydrofuran / 20 °C
4: 90 percent / aq. HBr / 3 h / Heating
5: 62 percent / sodium bicarbonate / dioxane; H2O / -2 - 20 °C
6: 58 percent / triethylamine / ethanol / 2 h / Heating
View Scheme
参考文献
Hirsh, Andrew J.; Molino, Bruce F.; Zhang, Jianzhong; Astakhova, Nadezhda; Geiss, William B.; Sargent, Bruce J.; Swenson, Brian D.; Usyatinsky, Alexander; Wyle, Michael J.; Boucher, Richard C.; Smith, Rick T.; Zamurs, Andra; Johnson, M. Ross
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4098 - 4115
反应条件
1: PBr3 / CCl4
2: (i) NaH, THF, (ii) /BRN= 1944343/
3: PdCl2, CuCl2, NaOAc / acetic acid
View Scheme
参考文献
Mori,M.; Ban,Y.
Chemical and Pharmaceutical Bulletin, 1976 , vol. 24, p. 1992 - 1999
