1-苯基-3,4-二氢异喹啉合成路线 （共 40 条）
参考文献
Pictet; Kay
Chemische Berichte, 1909 , vol. 42, p. 1977
反应条件
phosphoric acid; hydrogen; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; (S)-2,2',6,6'-tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine in tetrahydrofuran; water T=60°C; P=2250.23 - 22502.3 Torr; Parr autoclaveInert atmosphere; Product distribution / selectivity;
参考文献
WO2010/12459 A2, ;
Page/Page column 30 ;
反应条件
sodium tetrahydroborate in ethanol T=20°C; 60 h;
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 21 p. 6597 - 6606
反应条件
1: 72 percent / toluene / 32 h / 90 °C 2: 97 percent / H2; PtO2 / ethanol / 24 h / 3000.24 Torr View Scheme
参考文献
Hoefgen, Barbara; Decker, Michael; Mohr, Patrick; Schramm, Astrid M.; Rostom, Sherif A. F.; El-Subbagh, Hussein; Schweikert, Peter M.; Rudolf, Dirk R.; Kassack, Matthias U.; Lehmann, Jochen
Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 760 - 769
反应条件
methanol; sodium tetrahydroborate in water T=20 - 34°C; 5.41667 h;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2008/128028 A2, 2008 ;
Location in patent: Page/Page column 28 ;
反应条件
di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; (R)-3,5-diMe-Synphos; hydrogen in 1,4-dioxane T=40°C; P=22502.3 Torr; 18 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Organic Letters, , vol. 14, # 13 p. 3308 - 3311
反应条件
di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; (R)-3,5-diMe-Synphos; hydrogen; potassium carbonate in 1,4-dioxane T=40°C; P=22502.3 Torr; 18 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Berhal, Farouk; Wu, Zi; Zhang, Zhaoguo; Ayad, Tahar; Ratovelomanana-Vidal, Virginie
Organic Letters, 2012 , vol. 14, # 13 p. 3308 - 3311
参考文献
Brodrick; Short
Journal of the Chemical Society, 1949 , p. 2587
反应条件
1: H2 / PtO2 / ethanol / 10 h / 2792.6 Torr
2: 65 percent / 50percent aq. NaOH, benzyltriethylammonium chloride / CH2Cl2 / 0.25 h / Ambient temperature
View Scheme
参考文献
Gray, Nancy M.; Cheng, Brian K.; Mick, Stephen J.; Lair, Cecelia M.; Contreras, Patricia C.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1242 - 1248
反应条件
1: 50 percent / acide m-chloroperbenzoique / CH2Cl2 / 1 h
2: 95 percent / acide sulfurique, chlorure de toluene-p-sulfonyle / benzene; H2O / 16 h
View Scheme
参考文献
Cherest, M.; Lusinchi, X.
Tetrahedron, 1982 , vol. 38, # 23 p. 3471 - 3478
