dirhodium tetraacetate in dichloromethane 24 h;

Grubb's 2nd generation catalyst in dichloromethane T=20°C;

pyridine; iodobenzene dichloride in dichloromethane T=20°C; 0.0833333 h;

1: 92 percent / ethyldiisopropylamine / diethyl ether 2: 89 percent / propylene oxide; [Rh2(OAc)4] / toluene / 40 °C View Scheme

Grubb's 2nd generation catalyst in dichloromethane T=20°C;

(i) BF3-Et2O, (ii) H2, Pd-C, EtOH; Multistep reaction;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '2172036', constants.ctx, '0')">N,N'-di-p-toluenesulfonylhydrazine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '508906', constants.ctx, '0')">1,8-diazabicyclo[5.4.0]undec-7-ene</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=0 - 20&deg;C;&nbsp;0.583333&nbsp;h;&nbsp;&nbsp;Sealed tubeInert atmosphere;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 5 h / Heating<br />2: Et₃N; tosyl azide / acetonitrile / 10 h / 20 &deg;C<br />3: 68 percent / aq. KOH / acetonitrile / 1 h<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11342940', constants.ctx, '0')">sodium hydroxide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1213605', constants.ctx, '0')">4-toluenesulfonyl azide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3637302', constants.ctx, '0')">Tetrahexylammonium bromide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />T=20&deg;C;&nbsp;25&nbsp;h;&nbsp;<br /> &nbsp;

Stage #1: <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '507140', constants.ctx, '0')"><i>N</i>,<i>N</i>-dimethyl-aniline</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=0&deg;C;&nbsp;0.5&nbsp;h;&nbsp;<br />Stage #2: <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=0 - 20&deg;C;&nbsp;1.5&nbsp;h;&nbsp;&nbsp;Further stages.;&nbsp;<br /> &nbsp;