3-(3-氨基苯基)-1-丙醇合成路线 （共 7 条）
反应条件
hydrogenchloride; sodium nitrite
1.) H2O; 2.) 0-5 deg C 30 min, room temp. 4 h; Multistep reaction;
参考文献
Vieweg; Wagner
Pharmazie, 1982 , vol. 37, # 3 p. 178 - 182
反应条件
hydrogen; palladium 10 on activated carbon in methanol
P=2585.81 Torr;
参考文献
INCYTE CORPORATION
Patent: US2010/190804 A1, 2010 ;
Location in patent: Page/Page column 74 ;
US 20100190804 A1
反应条件
hydrogen; palladium 10 on activated carbon
P=1965.21 Torr;
参考文献
IMOTEP INC.
Patent: WO2004/106291 A1, 2004 ;
Location in patent: Page 76 ;
反应条件
hydrogen; nickel in methanol
P=760 Torr;
参考文献
Vieweg; Wagner
Pharmazie, 1982 , vol. 37, # 3 p. 178 - 182
反应条件
1: With borane-THF in tetrahydrofuran
T=0 - 20°C;
2: With sodium hydroxide in tetrahydrofuran; water
T=20°C; 4 h;
参考文献
Ortho-McNeil Pharmaceutical, Inc.
Patent: EP1027342 B1, 2004 ;
Location in patent: Page 24 ;
反应条件
1: 68 percent / NaBH4 / methanol
2: 85 percent / H2 / Raney-Ni / methanol / 760 Torr
View Scheme
参考文献
Vieweg; Wagner
Pharmazie, 1982 , vol. 37, # 3 p. 178 - 182
参考文献
Stawrowskaja; Toptschiew
Doklady Akademii Nauk SSSR, 1947 , vol. 58, p. 237,239
Chem.Abstr., 1951 , p. 6593
