6-溴-1,4-苯并恶烷合成路线 （共 14 条）
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide T=20°C;
参考文献
Duprat De Paule, Sebastien; Champion, Nicolas; Vidal, Virginie; Genet, Jean-Pierre; Dellis, Philippe
Patent: US2004/260101 A1, 2004 ;
Location in patent: Page 5-6 ;
反应条件
1: 57 percent / NaOH / dimethylsulfoxide 2: 66.4 percent / Br2 / acetic acid View Scheme
参考文献
Ghosh
Journal of the Chemical Society, 1915 , vol. 107, p. 1595
反应条件
1: 57 percent / tri(o-tolyl)phosphine; tris(dibenzylideneacetone)dipalladium(0); sodium t-butoxide / toluene / 18 h / Heating 2: 75 percent / trifluoroacetic acid / CH2Cl2 / 1 h / 0 °C View Scheme
参考文献
Song, Jiho; Kim, Young Jin; Min, Kyung Hoon; Lee, Hyun-E; Kim, Su Yeon; Kim, Dong-Seok
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6943 - 6946,4
反应条件
[PhCOPd(PtBu3)I]; dtbpf in 2-methyl tetrahydrofuran T=80°C; 18 h; Inert atmosphere;
参考文献
Korsager, Signe; Taaning, Rolf H.; Skrydstrup, Troels
Journal of the American Chemical Society, 2013 , vol. 135, # 8 p. 2891 - 2894
反应条件
dichloro(cycloocta-1,5-diene)palladium(II); N,N-dicyclohexylmethylamine; potassium formiate; tetra-(n-butyl)ammonium iodide; PCy3∙HBF4; bis(dibenzylideneacetone)-palladium(0); [(t-Bu)3PH]BF4 T=100°C; 18 h; Sealed tubeGloveboxInert atmosphere; Reagent/catalystSolvent;
参考文献
Korsager, Signe; Taaning, Rolf H.; Lindhardt, Anders T.; Skrydstrup, Troels
Journal of Organic Chemistry, 2013 , vol. 78, # 12 p. 6112 - 6120
参考文献
Journal of the Chemical Society, , p. 18,21
反应条件
1: 6-bromo-2,3-dihydro-1,4-benzodioxine With magnesium in diethyl ether T=10°C; 2: allyl bromide in diethyl ether 3 h; Heating;
参考文献
Mochalov; Gazzaeva; Fedotov; Trofimova; Trushkov; Zefirov
Russian Journal of Organic Chemistry, 2004 , vol. 40, # 8 p. 1098 - 1112
反应条件
1: 1.) Mg / 1.) THF 2: 46.7 percent / 60 h / 145 °C View Scheme
参考文献
Biernacki, Wladyslaw; Sobotka, Wieslaw
Polish Journal of Chemistry, 1980 , vol. 54, # 11/12 p. 2239 - 2242
反应条件
1: 6-bromo-2,3-dihydro-1,4-benzodioxine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: monobromoacetic acid in tetrahydrofuran; hexane T=-78 - 20°C; Further stages.;
参考文献
Harrak; Rosell; Daidone; Plescia; Schillaci; Pujol
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 14 p. 4876 - 4890
反应条件
bis (triortho-tolylphosphine)palladium(II) chloride; pyridine-3-carboxamide; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl T=150°C; 16 h; Inert atmosphere;
参考文献
Romero; Harrak; Basset; Orue; Pujol
Tetrahedron, 2009 , vol. 65, # 10 p. 1951 - 1956
