6-溴-1,4-苯并恶烷合成路线 （共 14 条）
反应条件
1: 6-bromo-2,3-dihydro-1,4-benzodioxine With n-butyllithium in tetrahydrofuran
T=-70°C;
2: chloro-diphenylphosphine T=-70 - 20°C;
3: With dihydrogen peroxide in methanol
T=0°C;
参考文献
Duprat De Paule, Sebastien; Jeulin, Severine; Ratovelomanana-Vidal, Virginie; Genet, Jean-Pierre; Champion, Nicolas; Dellis, Philippe
Tetrahedron Letters, 2003 , vol. 44, # 4 p. 823 - 826
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 1.17 h / -78 °C
1.2: tetrahydrofuran; hexane / -70 - 0 °C
2.1: aq. H2O2 / methanol / 1 h / 20 °C
View Scheme
参考文献
Duprat De Paule, Sebastien; Jeulin, Severine; Ratovelomanana-Vidal, Virginie; Genet, Jean-Pierre; Champion, Nicolas; Deschaux, Gilles; Dellis, Philippe
Organic Process Research and Development, 2003 , vol. 7, # 3 p. 399 - 406
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 1.17 h / -78 °C
1.2: tetrahydrofuran; hexane / -70 - 0 °C
2.1: aq. H2O2 / methanol / 1 h / 20 °C
3.1: t-BuLi / pentane; tetrahydrofuran / 3.5 h / -100 - -70 °C
3.2: I2 / pentane; tetrahydrofuran / 2 h / -70 - 0 °C
View Scheme
参考文献
Duprat De Paule, Sebastien; Jeulin, Severine; Ratovelomanana-Vidal, Virginie; Genet, Jean-Pierre; Champion, Nicolas; Deschaux, Gilles; Dellis, Philippe
Organic Process Research and Development, 2003 , vol. 7, # 3 p. 399 - 406
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 1.17 h / -78 °C
1.2: tetrahydrofuran; hexane / -70 - 0 °C
2.1: aq. H2O2 / methanol / 1 h / 20 °C
3.1: t-BuLi / pentane; tetrahydrofuran / 3.5 h / -100 - -70 °C
3.2: I2 / pentane; tetrahydrofuran / 2 h / -70 - 0 °C
4.1: Cu / dimethylformamide / 4 h / 140 °C
5.1: (+)-O,O-dibenzoyltartaric acid / CH2Cl2
5.2: aq. CH2Cl2 / CH2Cl2 / 0.5 h
6.1: 91 percent / NBu3; HSiCl3 / xylene / 140 °C
View Scheme
参考文献
Duprat De Paule, Sebastien; Jeulin, Severine; Ratovelomanana-Vidal, Virginie; Genet, Jean-Pierre; Champion, Nicolas; Dellis, Philippe
Tetrahedron Letters, 2003 , vol. 44, # 4 p. 823 - 826
