4-甲氧基-2甲基苯甲醛合成路线 （共 35 条）
反应条件
dipotassium peroxodisulfate; copper(II) sulfate in water; acetonitrile 0.5 h; Heating;
参考文献
Hauser, Frank M.; Ellenberger, Suzanne R.
Synthesis, 1987 , # 8 p. 723 - 724
反应条件
magnesium 1.) THF; Multistep reaction;
参考文献
Quinkert; Weber; Schwartz; Duerner
Angewandte Chemie, 1980 , vol. 92, # 12 p. 1060 - 1062
反应条件
dipotassium peroxodisulfate; copper(II) sulfate in water; acetonitrile 0.5 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/66136 A1, 2005 ;
Location in patent: Page/Page column 60 ;
WO 2005/066136 A1
反应条件
1: With hydrogenchloride in tetrachloroethane, 1,1,2,2- T=17°C; 2: With aluminium trichloride in tetrachloroethane, 1,1,2,2- T=55°C; 3 h;
参考文献
Schmidt, Jonathan M.; Mercure, Julie; Tremblay, Gilles B.; Page, Martine; Kalbakji, Aida; Feher, Miklos; Dunn-Dufault, Robert; Peter, Markus G.; Redden, Peter R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1408 - 1418
反应条件
Florisil; Celite; pyridinium chlorochromate in dichloromethane 1.3 h; Ambient temperature;
参考文献
Shishido; Yamashita; Hiroya; Fukumoto; Kametani
Tetrahedron, 1989 , vol. 45, # 18 p. 5791 - 5804
反应条件
1: 90 percent / Br2, Fe powder / CCl4 / 2 h / below 0 deg C 2: 1.) EtBr, Mg / 1.) Et2O, reflux, 1 h, 2.) < 0 deg C, 1 h View Scheme
参考文献
Quinkert; Weber; Schwartz; et al.
1981 , vol. No. 12, p. 2335 - 2371
反应条件
1: 1.) n-BuLi, 2.) MgBr2 / 1.) ether, hexane, -78 deg C, 5 min, 2.) warmed to room temperature 2: 280 mg / 50percent NaOH / ethanol / 2 h / Heating View Scheme
参考文献
Dhawan, Kasturi L.; Gowland, Barbara D.; Durst, Tony
Journal of Organic Chemistry, 1980 , vol. 45, # 5 p. 922 - 924
反应条件
1: 78 percent / benzyltriethylammonium chloride, 50percent NaOH / CH2Cl2 / 0 °C 2: 1.) n-BuLi, 2.) MgBr2 / 1.) ether, hexane, -78 deg C, 5 min, 2.) warmed to room temperature 3: 280 mg / 50percent NaOH / ethanol / 2 h / Heating View Scheme
参考文献
Akguen, Eyup; Glinski, Margaret B.; Dhawan, Kasturi L.; Durst, Tony
Journal of Organic Chemistry, 1981 , vol. 46, # 13 p. 2730 - 2734
反应条件
1: 90 percent / pyridinium chlorochromate / oxidation 2: 78 percent / benzyltriethylammonium chloride, 50percent NaOH / CH2Cl2 / 0 °C 3: 1.) n-BuLi, 2.) MgBr2 / 1.) ether, hexane, -78 deg C, 5 min, 2.) warmed to room temperature 4: 280 mg / 50percent NaOH / ethanol / 2 h / Heating View Scheme
参考文献
Akguen, Eyup; Glinski, Margaret B.; Dhawan, Kasturi L.; Durst, Tony
Journal of Organic Chemistry, 1981 , vol. 46, # 13 p. 2730 - 2734
反应条件
oxygen; Titanium(IV) oxide; silver sulphate in acetonitrile 2 h; Ambient temperatureIrradiation;
参考文献
Baciocchi; Rosato; Rol; Sebastiani
Tetrahedron Letters, 1992 , vol. 33, # 37 p. 5437 - 5440
