1: 89 percent / i-Pr2NEt / dioxane / 72 h / 50 °C 2: 81 percent / O3 / methanol / 0.67 h / -20 °C 3: 86 percent / methanol; tetrahydrofuran; H2O / 17 h / Ambient temperature 4: 1.) NaBH4, 2.) methacryloyl chloride / 1.) DMF, -20 deg C, 2.5 h, 2.) DMF, 0 deg C, 3 h View Scheme

1: 97 percent / Et3N / CH2Cl2 / 1 h / Ambient temperature 2: 89 percent / i-Pr2NEt / dioxane / 72 h / 50 °C 3: 81 percent / O3 / methanol / 0.67 h / -20 °C 4: 86 percent / methanol; tetrahydrofuran; H2O / 17 h / Ambient temperature 5: 1.) NaBH4, 2.) methacryloyl chloride / 1.) DMF, -20 deg C, 2.5 h, 2.) DMF, 0 deg C, 3 h View Scheme

1: 86 percent / methanol; tetrahydrofuran; H2O / 17 h / Ambient temperature 2: 1.) NaBH4, 2.) methacryloyl chloride / 1.) DMF, -20 deg C, 2.5 h, 2.) DMF, 0 deg C, 3 h View Scheme

1: 81 percent / O3 / methanol / 0.67 h / -20 °C 2: 86 percent / methanol; tetrahydrofuran; H2O / 17 h / Ambient temperature 3: 1.) NaBH4, 2.) methacryloyl chloride / 1.) DMF, -20 deg C, 2.5 h, 2.) DMF, 0 deg C, 3 h View Scheme

sodium tetrahydroborate; 2-methyl-acryloyl chloride 1.) DMF, -20 deg C, 2.5 h, 2.) DMF, 0 deg C, 3 h; Yield given. Multistep reaction;

(i) NaBH4, DMF, (ii) /BRN= 878175/; Multistep reaction;