2,2-二甲基-2,6-二氢-吡喃并[3,2-c]喹啉-5-酮合成路线 （共 37 条）
反应条件
magnesium sulfate in pyridine
参考文献
de Groot,A.; Jansen,B.J.M.
Tetrahedron Letters, 1975 , p. 3407 - 3410
反应条件
hydrogen bromide
T=70°C; 4 h;
参考文献
Bowman,R.M. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1973 , p. 1055 - 1059
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in benzene
Heating;
参考文献
Maat,L. et al.
Recueil des Travaux Chimiques des Pays-Bas, 1973 , vol. 92, p. 1399 - 1400
反应条件
trichlorophosphate in chloroform
210 h; Heating;
参考文献
Reisch, Johannes; Bathe, Andreas; Salehi-Artimani, Reza A.
Archiv der Pharmazie (Weinheim, Germany), 1986 , vol. 319, # 8 p. 720 - 727
反应条件
1: 67 percent / polyphosphoric acid / xylene / 10 h / 20 - 145 °C
2: 85 percent / DDQ / benzene / 12 h / Heating
View Scheme
参考文献
Thangavel, Dhanabal; Ravindran, Sangeetha; Moonsamy, Gengan Robert; Palathurai, Mohan Subramaniam
Journal of Chemical Research, 2007 , # 2 p. 124 - 126
反应条件
1: 82 percent / dioxane / 4.5 h / 120 °C
2: 90 percent / DDQ / benzene / 15 h / Heating
View Scheme
参考文献
Suresh; Dhanabal; Nandha Kumar; Mohan
Heterocyclic Communications, 2005 , vol. 11, # 1 p. 79 - 84
反应条件
1: 1.) NaH / 1.) DMF, overnight, 2.) DMF, 4 h
2: 75 percent / 1,2-dichloro-benzene / 2 h / Heating
3: 77 percent / Br2 / CHCl3
4: 71 percent / phosphoryl chloride / 4 h / Heating
5: 1.) Br2, 2.) LiBr, Li2CO3 / 1.) glacial acetic acid, 2.) DMF, reflux, 5 h
6: 72 percent / 6N aq. HCl / methanol / 30 h / Heating
7: 2.4 g / NaBH4 / methanol
8: 81.5 percent / POCl3, pyridine / 1.5 h / Heating
View Scheme
参考文献
Anand, R C; Sinha, A K
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 6 p. 560 - 562
反应条件
1: 77 percent / Br2 / CHCl3
2: 71 percent / phosphoryl chloride / 4 h / Heating
3: 1.) Br2, 2.) LiBr, Li2CO3 / 1.) glacial acetic acid, 2.) DMF, reflux, 5 h
4: 72 percent / 6N aq. HCl / methanol / 30 h / Heating
5: 2.4 g / NaBH4 / methanol
6: 81.5 percent / POCl3, pyridine / 1.5 h / Heating
View Scheme
参考文献
Anand, R C; Sinha, A K
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 6 p. 560 - 562
反应条件
1: 1.) Br2, 2.) LiBr, Li2CO3 / 1.) glacial acetic acid, 2.) DMF, reflux, 5 h
2: 72 percent / 6N aq. HCl / methanol / 30 h / Heating
3: 2.4 g / NaBH4 / methanol
4: 81.5 percent / POCl3, pyridine / 1.5 h / Heating
View Scheme
参考文献
Anand, R C; Sinha, A K
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 6 p. 560 - 562
反应条件
1: 72 percent / 6N aq. HCl / methanol / 30 h / Heating
2: 2.4 g / NaBH4 / methanol
3: 81.5 percent / POCl3, pyridine / 1.5 h / Heating
View Scheme
参考文献
Anand, R C; Sinha, A K
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 6 p. 560 - 562
