2,2-二甲基-2,6-二氢-吡喃并[3,2-c]喹啉-5-酮合成路线 （共 37 条）
反应条件
1: 71 percent / phosphoryl chloride / 4 h / Heating
2: 1.) Br2, 2.) LiBr, Li2CO3 / 1.) glacial acetic acid, 2.) DMF, reflux, 5 h
3: 72 percent / 6N aq. HCl / methanol / 30 h / Heating
4: 2.4 g / NaBH4 / methanol
5: 81.5 percent / POCl3, pyridine / 1.5 h / Heating
View Scheme
参考文献
Anand, R C; Sinha, A K
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 6 p. 560 - 562
反应条件
1: 75 percent / 1,2-dichloro-benzene / 2 h / Heating
2: 77 percent / Br2 / CHCl3
3: 71 percent / phosphoryl chloride / 4 h / Heating
4: 1.) Br2, 2.) LiBr, Li2CO3 / 1.) glacial acetic acid, 2.) DMF, reflux, 5 h
5: 72 percent / 6N aq. HCl / methanol / 30 h / Heating
6: 2.4 g / NaBH4 / methanol
7: 81.5 percent / POCl3, pyridine / 1.5 h / Heating
View Scheme
参考文献
Anand, R C; Sinha, A K
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 6 p. 560 - 562
反应条件
1: 1.) NaH / 1.) DMF, overnight, 2.) DMF, 4 h
2: 75 percent / 1,2-dichloro-benzene / 2 h / Heating
3: 77 percent / Br2 / CHCl3
4: 71 percent / phosphoryl chloride / 4 h / Heating
5: 1.) Br2, 2.) LiBr, Li2CO3 / 1.) glacial acetic acid, 2.) DMF, reflux, 5 h
6: 72 percent / 6N aq. HCl / methanol / 30 h / Heating
7: 2.4 g / NaBH4 / methanol
8: 81.5 percent / POCl3, pyridine / 1.5 h / Heating
View Scheme
参考文献
Anand, R C; Sinha, A K
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 6 p. 560 - 562
反应条件
1: aq. KOH / dimethylsulfoxide / 15 h / 100 °C
2: aq. HBr / 4 h / 70 °C
View Scheme
参考文献
Bowman,R.M. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1973 , p. 1055 - 1059
反应条件
1: MCPBA / CHCl3 / 96 h / Ambient temperature
2: aq. KOH / dimethylsulfoxide / 15 h / 100 °C
3: aq. HBr / 4 h / 70 °C
View Scheme
参考文献
Bowman,R.M. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1973 , p. 1055 - 1059
参考文献
Reisch, Johannes; Bathe, Andreas; Rosenthal, Bernd H. W.; Salehi-Artimani, Reza A.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 869 - 872
参考文献
Huffman,J.W.; Hsu,T.M.
Tetrahedron Letters, 1972 , p. 141 - 143
