(2-氯-4硝基苄醇)甲醇合成路线 （共 7 条）
反应条件
1: With diisobutylaluminium hydride in hexane; dichloromethane T=-78°C; 4 h; Inert atmosphere; 2: With water in hexane; dichloromethane T=20°C; 0.333333 h; Inert atmosphere;
参考文献
CHLORION PHARMA, INC.; UNIVERSITE LAVAL; ATTARDO, Giorgio; TRIPATHY, Sasmita
Patent: WO2010/132999 A1, 2010 ;
Location in patent: Page/Page column 91 ;
反应条件
1: With 1,1'-carbonyldiimidazole in tetrahydrofuran T=35°C; 1.5 h; 2: With sodium tetrahydroborate in tetrahydrofuran; water T=20°C; 1.5 h; 3: With hydrogenchloride in tetrahydrofuran; water 1 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2005/63239 A1, 2005 ;
Location in patent: Page/Page column 154 ;
WO 2005/063239 A1
反应条件
sodium tetrahydroborate in methanol; ethylene glycol dimethyl ether Product distribution / selectivity;
参考文献
N.V. ORGANON; PHARMACOPEIA INC.
Patent: WO2008/51826 A2, 2008 ;
Location in patent: Page/Page column 56-58 ;
WO 2008/051826 A2
反应条件
1: With phosphorus tribromide in dichloromethane
T=0 - 20°C; Inert atmosphere;
2: With sodium hydrogencarbonate in dichloromethane
Inert atmosphere;
参考文献
CHLORION PHARMA, INC.; UNIVERSITE LAVAL; ATTARDO, Giorgio; TRIPATHY, Sasmita
Patent: WO2010/132999 A1, 2010 ;
Location in patent: Page/Page column 91 ;
反应条件
thionyl chloride in dichloromethane; N,N-dimethyl-formamide
2 h; Heating / reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2005/63239 A1, 2005 ;
Location in patent: Page/Page column 155 ;
WO 2005/063239 A1
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane
T=-70°C; Swern Oxidation; 1 h;
2: With triethylamine in dichloromethane
T=20°C;
参考文献
N.V. ORGANON; PHARMACOPEIA INC.
Patent: WO2008/51826 A2, 2008 ;
Location in patent: Page/Page column 57; 58 ;
WO 2008/051826 A2
反应条件
hydrogenchloride
T=100°C;
参考文献
Witt
Chemische Berichte, 1892 , vol. 25, p. 83
