2-氯-5-三氟甲基吡啶合成路线 （共 80 条）
参考文献
European Journal of Medicinal Chemistry, , vol. 24, # 3 p. 249 - 258
反应条件
potassium hydroxide in tert-butyl alcohol 1 h; Heating;
参考文献
Haga, Takahiro; Fujikawa, Kan-ichi; Koyanagi, Tohru; Nakajima, Toshio; Hayashi, Kouji
Heterocycles, 1984 , vol. 22, # 1 p. 117 - 124
反应条件
1: 2-hydroxyisobutyric acid ethyl ester With potassium hexamethylsilazane in tetrahydrofuran T=-70 - -62°C; 0.5 h; 2: 2-chloro-5-(trifluoromethyl)-pyridine in tetrahydrofuran T=-62 - 20°C; 16 h; 3: With sodium hydroxide in tetrahydrofuran; water 22 h; Heating / reflux;
参考文献
MERCK and CO., INC.
Patent: WO2005/9479 A1, 2005 ;
Location in patent: Page/Page column 39 ;
WO 2005/009479 A1
反应条件
in N,N-dimethyl-formamide T=20°C; 2 h;
参考文献
IRM LLC
Patent: WO2008/157210 A1, 2008 ;
Location in patent: Page/Page column 17 ;
WO 2008/157210 A1
反应条件
potassium hydroxide in water; N,N-dimethyl-formamide T=35°C; Ullmann Condensation; 12 h; Inert atmosphere;
参考文献
Dhital, Raghu Nath; Kamonsatikul, Choavarit; Somsook, Ekasith; Sakurai, Hidehiro
Catalysis Science and Technology, 2013 , vol. 3, # 11 p. 3030 - 3035
反应条件
1: 1-(2-bromopyridine-5-yl)-2,5-dimethyl-1H-pyrrole With tert.-butyl lithium in tetrahydrofuran; pentane T=-78°C; Negishi coupling reaction; 2: With zinc(II) chloride in tetrahydrofuran; pentane T=20°C; 3: 2-chloro-5-(trifluoromethyl)-pyridine With Pd0(tris(tert-butyl)phosphine)2 in tetrahydrofuran; pentane Heating; Title compound not separated from byproducts;
参考文献
Luetzen, Arne; Hapke, Marko; Staats, Holger; Bunzen, Jens
European Journal of Organic Chemistry, 2003 , # 20 p. 3948 - 3957
反应条件
hydrogenchloride; sodium sulfite 1.) EtOH, H2O, 140 deg C, 10.5 h; Yield given. Multistep reaction;
参考文献
Umemoto, Teruo; Tomizawa, Ginjiro
Journal of Organic Chemistry, 1995 , vol. 60, # 20 p. 6563 - 6570
反应条件
1: 2-chloro-5-(trifluoromethyl)-pyridine With n-butyllithium; diisopropylamine; sodium bromide in tetrahydrofuran; hexane T=-75°C; 2 h; 2: carbon dioxide in tetrahydrofuran; hexane 3: With sodium hydroxide in tetrahydrofuran; hexane
参考文献
Cottet, Fabrice; Schlosser, Manfred
European Journal of Organic Chemistry, 2004 , # 18 p. 3793 - 3798
反应条件
1.1: lithium N,N-diisopropylcarbamate; diisopropylamine; lithium bromide / tetrahydrofuran; hexane / 2 h / -75 °C 1.2: 67 percent / iodine / tetrahydrofuran; hexane / 0.75 h / -75 °C 2.1: 46 percent / piperidine; butyllithium / tetrahydrofuran; hexane / 20 h / -75 °C 3.1: 65 percent / butyllithium / hexane; tetrahydrofuran / 0.25 h / -75 °C View Scheme
参考文献
Cottet, Fabrice; Marull, Marc; Lefebvre, Olivier; Schlosser, Manfred
European Journal of Organic Chemistry, 2003 , # 8 p. 1559 - 1568
反应条件
in 1-methyl-pyrrolidin-2-one; water T=20°C; 3 h;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED; TAKAHASHI, Masaki; IWAKOSHI, Mitsuhiko; IKEGAMI, Hiroshi
Patent: WO2010/125985 A1, 2010 ;
Location in patent: Page/Page column 240-241 ;
