2-氯-5-三氟甲基吡啶合成路线 （共 80 条）
反应条件
4 h; Refluxneat (no solvent);
参考文献
Kodimuthali, Arumugam; Mungara, Anitha; Prasunamba, Padala Lakshmi; Pal, Manojit
Journal of the Brazilian Chemical Society, 2010 , vol. 21, # 8 p. 1439 - 1445
反应条件
36 h; Refluxneat (no solvent);
参考文献
Kodimuthali, Arumugam; Mungara, Anitha; Prasunamba, Padala Lakshmi; Pal, Manojit
Journal of the Brazilian Chemical Society, 2010 , vol. 21, # 8 p. 1439 - 1445
反应条件
trimethylsilyl bromide in various solvent(s) 20 h; Heating;
参考文献
Cottet, Fabrice; Marull, Marc; Lefebvre, Olivier; Schlosser, Manfred
European Journal of Organic Chemistry, 2003 , # 8 p. 1559 - 1568
反应条件
1: With n-butyllithium; diisopropylamine; sodium bromide in tetrahydrofuran; hexanes T=-78 - 0°C; 1.16667 h; 2: With iodine in tetrahydrofuran; hexanes T=-78°C; 2 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2008/94992 A2, 2008 ;
Location in patent: Page/Page column 174 ;
WO 2008/094992 A2
反应条件
1.1: lithium N,N-diisopropylcarbamate; diisopropylamine; lithium bromide / tetrahydrofuran; hexane / 2 h / -75 °C 1.2: 67 percent / iodine / tetrahydrofuran; hexane / 0.75 h / -75 °C 2.1: 46 percent / piperidine; butyllithium / tetrahydrofuran; hexane / 20 h / -75 °C View Scheme
参考文献
Cottet, Fabrice; Marull, Marc; Lefebvre, Olivier; Schlosser, Manfred
European Journal of Organic Chemistry, 2003 , # 8 p. 1559 - 1568
反应条件
1: With n-butyllithium; diisopropylamine; sodium bromide in tetrahydrofuran; hexanes T=-78 - 0°C; 1.16667 h; 2: With iodine in tetrahydrofuran; hexanes T=-78°C; 2 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2008/94992 A2, 2008 ;
Location in patent: Page/Page column 174 ;
WO 2008/094992 A2
反应条件
1: With diisopropylamine; lithium bromide; lithium N,N-diisopropylcarbamate in tetrahydrofuran; hexane T=-75°C; 2 h; 2: With iodine in tetrahydrofuran; hexane T=-75°C; 0.75 h;
参考文献
Cottet, Fabrice; Marull, Marc; Lefebvre, Olivier; Schlosser, Manfred
European Journal of Organic Chemistry, 2003 , # 8 p. 1559 - 1568
反应条件
ammonium hydroxide T=180°C; 8 h;
参考文献
Haga, Takahiro; Fujikawa, Kan-ichi; Koyanagi, Tohru; Nakajima, Toshio; Hayashi, Kouji
Heterocycles, 1984 , vol. 22, # 1 p. 117 - 124
反应条件
1: 2-chloro-5-(trifluoromethyl)-pyridine With n-butyllithium; diisopropylamine; sodium bromide in tetrahydrofuran; hexane T=-75°C; 2 h; 2: carbon dioxide in tetrahydrofuran; hexane 3: With sodium hydroxide in tetrahydrofuran; hexane
参考文献
Cottet, Fabrice; Schlosser, Manfred
European Journal of Organic Chemistry, 2004 , # 18 p. 3793 - 3798
反应条件
1.1: lithium N,N-diisopropylcarbamate; diisopropylamine; lithium bromide / tetrahydrofuran; hexane / 2 h / -75 °C 1.2: 67 percent / iodine / tetrahydrofuran; hexane / 0.75 h / -75 °C 2.1: 87 percent / butyllithium / hexane; tetrahydrofuran / 0.25 h / -75 °C View Scheme
参考文献
Cottet, Fabrice; Marull, Marc; Lefebvre, Olivier; Schlosser, Manfred
European Journal of Organic Chemistry, 2003 , # 8 p. 1559 - 1568
