2-氯-5-三氟甲基吡啶合成路线 （共 80 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60 - 95°C; 1 h;
参考文献
NOVARTIS AG
Patent: WO2008/110611 A1, 2008 ;
Location in patent: Page/Page column 122 ;
反应条件
aluminium trichloride
参考文献
Ishihara Sangyo Kaisha Ltd.
Patent: US4504665 A1, 1985 ;
反应条件
palladium dichloride
参考文献
Auerbach, Bruce J.; Bratton, Larry D.; Filzen, Gary F.; Geyer, Andrew G.; Trivedi, Bharat K.; Unangst, Paul C.
Patent: US2003/225158 A1, 2003 ;
Location in patent: Page 32 ;
反应条件
1: N,N-dimethyl-formamide / dichloromethane / 1 h / 40 °C 2: ammonia / 1,4-dioxane; water / 1 h / Cooling with ice 3: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.5 h / 0 °C / Inert atmosphere View Scheme
参考文献
Zhang, Xuqing; Sui, Zhihua; Lanter, James C.
Patent: US2011/306592 A1, 2011 ;
反应条件
1: With thiourea in ethanol T=20°C; 2 h; Heating / reflux; 2: With potassium hydroxide; water in ethanol T=20°C; 2 h; Heating / reflux; 3: With sodium hydroxide; acetic acid in ethanol; dichloromethane
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: WO2006/109729 A1, 2006 ;
Location in patent: Page/Page column 87 ;
反应条件
2,4,6-trimethyl-pyridine; hydrogen fluoride T=120°C; 1 h;
参考文献
Chemistry Letters, , # 3 p. 509 - 512
反应条件
iron(III) chloride in water
参考文献
Ishihara Sangyo Kaisha Ltd.
Patent: US4420618 A1, 1983 ;
参考文献
Ishihara Sangyo Kaisha Ltd.
Patent: US4420618 A1, 1983 ;
反应条件
aluminum oxide; potassium fluoride in N,N-dimethyl-formamide T=120°C; 9 h;
参考文献
Hwang, Ki-Jun; Park, Seung Ki
Synthetic Communications, 1990 , vol. 20, # 7 p. 949 - 954
反应条件
ammonium hydroxide T=135°C; 24 h;
参考文献
Haga, Takahiro; Fujikawa, Kan-ichi; Koyanagi, Tohru; Nakajima, Toshio; Hayashi, Kouji
Heterocycles, 1984 , vol. 22, # 1 p. 117 - 124
