N-(2-乙酰苯基)乙酰胺合成路线 （共 70 条）
反应条件
1: sodium hydroxide / methanol; water / 6 h / 20 °C
2: hydrogenchloride / water / 12 h / |Reflux
3: iodine / dimethyl sulfoxide / 12 h / 80 °C
View Scheme
参考文献
Sharma, Sahil; Thakur, Vikas; Ojha, Ritu; Budhiraja, Abhishek; Nepali, Kunal; Singh Bedi, Preet Mohinder
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 327 - 334
反应条件
1: sulfuric acid; nitric acid
2: aqueous hydrochloric acid
3: pyridine
4: iron; aqueous acetic acid
View Scheme
参考文献
Simpson et al.
Journal of the Chemical Society, 1945 , p. 646,655
反应条件
1: sulfuric acid; nitric acid
2: aqueous hydrochloric acid
3: pyridine
4: iron; aqueous acetic acid
5: aqueous sulfuric acid; sodium nitrite; copper sulfate
View Scheme
参考文献
Simpson et al.
Journal of the Chemical Society, 1945 , p. 646,655
参考文献
Camps
Chemische Berichte, 1899 , vol. 32, p. 3228
反应条件
potassium hydroxide; ethanol; hydroxylamine hydrochloride
参考文献
Amlaiky; Leclerc; Decker; Schwartz
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 5 p. 437 - 439
参考文献
Curran, Dennis P.; Kuo, Shen-Chun
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 2063 - 2065
反应条件
sodium tetrahydroborate
参考文献
Curran, Dennis P.; Kuo, Shen-Chun
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 2063 - 2065
反应条件
1: 68 percent / CuBr2 / ethyl acetate; CHCl3 / 8 h / Heating
2: 55 percent / concd HCl / ethanol / 2 h / 80 °C
View Scheme
参考文献
Alkhathlan, Hamad Z.; Al-Farhan, Khalid A.
Heterocycles, 1998 , vol. 48, # 4 p. 641 - 655
反应条件
sulfuric acid; nitric acid
T=4°C; 1.5 h; Acids were added over 0.5 h;
参考文献
Bristol-Myers Squibb Company
Patent: US6342079 B1, 2002 ;
Location in patent: Page column 3 ;
参考文献
Simpson
Journal of the Chemical Society, 1947 , p. 237
