4-氯-2-三氟甲基喹唑啉合成路线 (共 8 条)
反应条件
1: With phosphorus pentachloride; trichlorophosphate T=115 - 118°C; 4 h; 2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
Chandrika, P Mani; Yakaiah; Narsaiah; Sridhar; Venugopal; Rao, J Venkateshwara; Kumar, K Pranay; Murthy; Rao, A Raghu Ram
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009 , vol. 48, # 6 p. 840 - 847
反应条件
phosphorus pentachloride in anhydrous dichloroethane T=150°C; 0.5 h; Microwave irradiation;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2006/71958 A1, 2006 ;
Location in patent: Page/Page column 133 ;
WO 2006/071958 A1
反应条件
trichlorophosphate in toluene
参考文献
U.S. Philips Corporation
Patent: US3962444 A1, 1976 ;
反应条件
phosphorus pentachloride in sulfolane T=45 - 100°C; 16 h;
参考文献
Storz, Thomas; Heid, Richard; Zeldis, Joseph; Hoagland, Steven M.; Rapisardi, Vito; Hollywood, Susan; Morton, George
Organic Process Research and Development, 2011 , vol. 15, # 4 p. 918 - 924
反应条件
1: NaOEt / ethanol 2: POCl3; N,N-dimethylaniline / acetonitrile View Scheme
参考文献
Milhau, Ludovic; Guiry, Patrick J.
Synlett, 2011 , # 3 art. no. D31910ST, p. 383 - 385
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: Ac2O / 1 h / Heating 3: AcONH4 / 7 h / 220 °C 4: POCl3 / 3 h / Heating View Scheme
参考文献
Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
反应条件
1: Ac2O / 1 h / Heating 2: AcONH4 / 7 h / 220 °C 3: POCl3 / 3 h / Heating View Scheme
参考文献
Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
反应条件
1: AcONH4 / 7 h / 220 °C 2: POCl3 / 3 h / Heating View Scheme
参考文献
Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080