1,2,3,4-四氢-6-甲氧基-1-萘胺合成路线 （共 5 条）
反应条件
1: With titanium(IV) isopropylate; ammonia in ethanol T=20°C; 6 h; 2: With sodium tetrahydroborate in ethanol T=0 - 20°C; 3.16 h; 3: With hydrogenchloride; sodium hydroxide; ammonia more than 3 stages;
参考文献
PREDIX PHARMACEUTICALS HOLDINGS, INC.
Patent: WO2006/81332 A1, 2006 ;
Location in patent: Page/Page column 94-95 ;
WO 2006/081332 A1
反应条件
hydrogen; palladium on barium sulfate in ethanol P=760 Torr; 4 h; Ambient temperature;
参考文献
Guy, Alain; Lemor, Alain; Doussot, Joel; Lemaire, Marc
Synthesis, 1988 , # 11 p. 900 - 902
反应条件
1: Me3SiN3, DDQ / CHCl3 / 96 h / Ambient temperature 2: H2 / Pd-BaSO4 (5percent) / ethanol / 4 h / 760 Torr / Ambient temperature View Scheme
参考文献
Guy, Alain; Lemor, Alain; Doussot, Joel; Lemaire, Marc
Synthesis, 1988 , # 11 p. 900 - 902
反应条件
borane-THF; boron trifluoride diethyl etherate T=20°C; Title compound not separated from byproducts;
参考文献
Ortiz-Marciales, Margarita; Rivera, Luis D.; De Jesus, Melvin; Espinosa, Sandraliz; Benjamin, Josue A.; Casanova, Orlando E.; Figueroa, Irving G.; Rodriguez, Sheila; Correa, Wilbert
Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 10132 - 10134
反应条件
hydrogenchloride in diethyl ether
T=0°C; 0.5 h;
参考文献
Guy, Alain; Lemor, Alain; Doussot, Joel; Lemaire, Marc
Synthesis, 1988 , # 11 p. 900 - 902
