9-甲氧基-1,3-二氧杂环戊并[4,5-g]呋喃并[2,3-b]喹啉合成路线 （共 14 条）
反应条件
1: 1) Na / 2) MeOH, 35 h, reflux
2: Li, n-BuBr
3: 1) potassium t-butoxide / 1) ether, t-butylalcohol, 30 min, 0deg C, 2) THF, 6h, reflux
4: 78 percent / 3 percent hydrochloric acid / 5 h / heating on water-bath
5: 43 percent / orthophosphoric acid, phosphorous pentoxide / 36 h / Ambient temperature; 1) heating on water-bath, 2 h
View Scheme
参考文献
Ranade, A. C.; Mali, R. S.; Kurnawal, V. M.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 6 p. 528 - 529
反应条件
1: Li, n-BuBr
2: 1) potassium t-butoxide / 1) ether, t-butylalcohol, 30 min, 0deg C, 2) THF, 6h, reflux
3: 78 percent / 3 percent hydrochloric acid / 5 h / heating on water-bath
4: 43 percent / orthophosphoric acid, phosphorous pentoxide / 36 h / Ambient temperature; 1) heating on water-bath, 2 h
View Scheme
参考文献
Ranade, A. C.; Mali, R. S.; Kurnawal, V. M.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 6 p. 528 - 529
反应条件
1: 78 percent / 3 percent hydrochloric acid / 5 h / heating on water-bath
2: 43 percent / orthophosphoric acid, phosphorous pentoxide / 36 h / Ambient temperature; 1) heating on water-bath, 2 h
View Scheme
参考文献
Ranade, A. C.; Mali, R. S.; Kurnawal, V. M.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 6 p. 528 - 529
反应条件
(i) NBS, (irradiation), CCl4, (ii) collidine; Multistep reaction;
参考文献
Zimmer,H.; Walter,R.
Z. Naturforsch., B: Anorg. Chem., Org. Chem., Biochem., Biophys.,, 1963 , vol. 18, p. 669 - 670
