反应条件
1: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) DMF, 15 min, -18 deg C; 2.) 2 h, -10 - -20 deg C; 4 h, room temperature
2: 84 percent / H2 / Pd black / methanol / 12 h
3: 80 percent / HONB, DCCI / dimethylformamide / 1.) 2 h, -20 deg C; 2.) 3 h, room temperature
4: 98 percent / HCl, CH3COOH, C2H5SH / 0.75 h / Ambient temperature
View Scheme
参考文献
Henklein; Boomgaarden; Nieke; Georgi; Niedrich
Pharmazie, 1988 , vol. 43, # 1 p. 10 - 11
