反应条件
1: 1.) DCC, 1-hydroxybenzotriazole, 2.) Et3N / 1.) DMF, 20 deg C, 10 min, 2.) DMF, 20 deg C, 16 h
2: 1.) CH3I, 2.) NaH / 1.) 5 d, 2.) DMF, -40 - 3 deg C, 45 min
3: 94 percent / 2 M aq. NaOH / methanol / 18 h / 0 °C
View Scheme
参考文献
Deal, Martyn J.; Hagan, Russell M.; Ireland, Simon J.; Jordan, Christopher C.; McElroy, Andrew B.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4195 - 4204