5-(氯甲基)-2-甲基吡啶合成路线 (共 5 条)
反应条件
thionyl chloride in dichloromethane 0.5 h;
参考文献
EVOTEC NEUROSCIENCES GMBH
Patent: WO2009/135842 A1, 2009 ;
Location in patent: Page/Page column 175 ;
WO 2009/135842 A1
反应条件
sodium hydroxide in dichloromethane; water pH=7 - 8;
参考文献
Phan, Hieu Trung; Nguyen, Lan Mong; Azoulay, Raymond; Diep, Vinh Van; Eschenhof, Harald; Niesor, Eric Joseph; Bentzen, Craig Leigh; Ife, Robert John
Patent: US2005/124586 A1, 2005 ;
Location in patent: Page/Page column 7 ;
反应条件
1: LiAlH4 / tetrahydrofuran / 1 h / 20 °C 2: SOCl2 / 4 h / 20 °C View Scheme
参考文献
Dorsey; McDonough; McDaniel; Levin; Newton; Hoffman; Darke; Zugay-Murphy; Emini; Schleif; Olsen; Stahlhut; Rutkowski; Kuo; Lin; Chen; Michelson; Holloway; Huff; Vacca
Journal of Medicinal Chemistry, 2000 , vol. 43, # 18 p. 3386 - 3399
反应条件
in dimethyl sulfoxide
T=45 - 60°C; 0.25 h; Inert atmosphere;
参考文献
MEDIVATION TECHNOLOGIES, INC.; CHAKRAVARTY, Sarvajit; HART, Barry, Patrick; JAIN, Rajendra, Parasmal
Patent: WO2011/103460 A1, 2011 ;
Location in patent: Page/Page column 228 ;
反应条件
in dimethyl sulfoxide
T=100°C; 1 h;
参考文献
Chen, Chen; Wilcoxen, Keith M.; Huang, Charles Q.; Xie, Yun-Feng; McCarthy, James R.; Webb, Thomas R.; Zhu, Yun-Fei; Saunders, John; Liu, Xin-Jun; Chen, Ta-Kung; Bozigian, Haig; Grigoriadis, Dimitri E.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4787 - 4798