4,7-二甲氧基-1-茚酮合成路线 （共 9 条）
反应条件
scandium tris(trifluoromethanesulfonate) in nitromethane T=100°C; Friedel-Crafts acylation; 0.333333 h;
参考文献
Fillion, Eric; Fishlock, Dan; Wilsily, Ashraf; Goll, Julie M.
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1316 - 1327
反应条件
trifluoromethanesulfonic acid anhydride in 1,2-dichloro-ethane 8 h; Heating;
参考文献
Nenajdenko, Valentine G.; Baraznenok, Ivan L.; Balenkova, Elizabeth S.
Tetrahedron Letters, 1996 , vol. 37, # 24 p. 4199 - 4202
反应条件
aluminium trichloride in 1,2-dichloro-ethane 2 h; Ambient temperature;
参考文献
Al-Hamdany, Raad; Bruce, J. Malcolm; Heatley, Frank; Khalafy, Jabbar
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1985 , p. 1395 - 1400
反应条件
1.1: piperidinium acetate / ethanol / 0.5 h 1.2: 57 percent / NaBH3CN / ethanol / 0 - 20 °C 2.1: 32 percent / Sc(OTf)3 / nitromethane / 0.33 h / 100 °C View Scheme
参考文献
SUNSHINE LAKE PHARMA CO.,LTD.; ZHANG, Jiancun; ZHANG, Yingjun; XIE, Hongming; REN, Qingyun; HU, Bailin; FU, Changping; WU, Xiwei; LI, Shifeng; WANG, Chenglin; ZHANG, Zhikeng
Patent: WO2014/82379 A1, 2014 ;
反应条件
phosphorus pentoxide
参考文献
Arnold; Zaugg
Journal of the American Chemical Society, 1941 , vol. 63, p. 1317,1318
Full Text Show Details
Posternak; Castro
Helvetica Chimica Acta, 1948 , vol. 31, p. 536,539
反应条件
in 1,2-dichloro-ethane 8 h; Heating; Mechanism;
参考文献
Nenajdenko, Valentine G.; Baraznenok, Ivan L.; Balenkova, Elizabeth S.
Tetrahedron Letters, 1996 , vol. 37, # 24 p. 4199 - 4202
反应条件
hydrogenchloride in pyridine
T=165 - 170°C; 1.5 h;
参考文献
Al-Hamdany, Raad; Bruce, J. Malcolm; Heatley, Frank; Khalafy, Jabbar
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1985 , p. 1395 - 1400
反应条件
1: 80 percent / NaH / tetrahydrofuran / 14 h
2: 74 percent / H2, H(1+)
3: 95 percent / 2M NaOH, / methanol / 14 h / Ambient temperature
4: diethyl ether / 3 h / Ambient temperature
5: 49 percent / NaCl / ALCl3 / 0.12 h / 180 °C
6: 90 percent / TosOH / 40 h
7: 95 percent / CF3CO2Ag / CH2Cl2 / 0.12 h
8: 80 percent / m-CPBA / CH2Cl2 / 0.33 h / Ambient temperature
View Scheme
参考文献
Khanna; Mitscher
Tetrahedron Letters, 1985 , vol. 26, # 6 p. 691 - 694
反应条件
aluminium trichloride in nitrobenzene
T=70°C; 8 h;
参考文献
Horaguchi, Takaaki; Tamura, Shigeru; Hiratsuka, Naohiro; Suzuki, Tsuneo
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1001 - 1006
