1: diethyl malonate With sodium methylate in methanol
1 h; Heating / reflux;
2: 1-(bromomethyl)cyclopentane in methanol
3 h;
3: With hydrogenchloride; sodium hydroxide; water
more than 3 stages;
参考文献
Lee, Kwangho; Leeds, Jennifer A.
Patent: US2009/62537 A1, 2009 ;
Location in patent: Page/Page column 10-11 ;
US 20090062537 A1