1-(2-溴乙基)-4-(苯基甲氧基)苯合成路线 （共 9 条）
反应条件
in tetrahydrofuran; N,N-dimethyl-formamide; mineral oil
参考文献
Cherney, Robert J.; King, Bryan W.
Patent: US2002/86853 A1, 2002 ;
反应条件
in N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=125°C; 24 h;
参考文献
Albright; DeVries; Largis; Miner; Reich; Schaffer; Shepherd; Upeslacis
Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1378 - 1393
反应条件
1: 36 percent / hexamethylphosphoric acid triamide / 24 h / 125 °C
2: 67 percent / KOH / aq. ethanol / 5 h / Heating
View Scheme
参考文献
Albright; DeVries; Largis; Miner; Reich; Schaffer; Shepherd; Upeslacis
Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1378 - 1393
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane
T=0 - 20°C; 2 h;
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; BERNDT, Mathias; MUeLLER, Andre; SCHMITT-WILLICH, Heribert; STELLFELD, Timo; KETTSCHAU, Georg; BRUMBY, Thomas; GRAHAM, Keith; LEHMANN, Lutz; HAssFELD, Jorma; KRUeGER, Martin
Patent: WO2012/150220 A1, 2012 ;
Location in patent: Page/Page column 208-209 ;
参考文献
Rhone-Poulenc Rorer Pharmaceuticals, Inc.
Patent: US5674482 A1, 1997 ;
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
1.2: 20 - 50 °C
2.1: phosphorus tribromide / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Tokuyama, Hidetoshi; Okano, Kentaro; Fujiwara, Hideto; Noji, Toshiharu; Fukuyama, Tohru
Chemistry - An Asian Journal, 2011 , vol. 6, # 2 p. 560 - 572
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
1.2: 20 - 50 °C
2.1: phosphorus tribromide / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Tokuyama, Hidetoshi; Okano, Kentaro; Fujiwara, Hideto; Noji, Toshiharu; Fukuyama, Tohru
Chemistry - An Asian Journal, 2011 , vol. 6, # 2 p. 560 - 572
反应条件
triphenylphosphine; lithium bromide; diethylazodicarboxylate in tetrahydrofuran
12 h; 0 deg C -> r.t.; Yields of byproduct given;
参考文献
Di Grandi, Martin J.; Tilley, Jefferson W.
Tetrahedron Letters, 1996 , vol. 37, # 25 p. 4327 - 4330
反应条件
1: LiAlH4 / diethyl ether
2: PBr3 / benzene
View Scheme
参考文献
Van Dijk; Moed
Recueil des Travaux Chimiques des Pays Bas, 1973 , vol. 92, # 12 p. 1281 - 1297
