3’-氨基-2’,3’-双脱氧胸苷合成路线 （共 24 条）
反应条件
1: 95 percent / pyridine / 0 °C 2: 98 percent / DBU / 2 h / Heating 3: 85 percent / NaN3 / dimethylformamide / 120 °C 4: Dowex 50(H+) / methanol 5: H2 / Pd/C / methanol View Scheme
参考文献
Maillard, Michel; Faraj, Abdesslem; Frappier, Francois; Florent, Jean-Claude; Grierson, David S.; Monneret, Claude
Tetrahedron Letters, 1989 , vol. 30, # 15 p. 1955 - 1958
反应条件
1: 98 percent / DBU / 2 h / Heating 2: 85 percent / NaN3 / dimethylformamide / 120 °C 3: Dowex 50(H+) / methanol 4: H2 / Pd/C / methanol View Scheme
参考文献
Maillard, Michel; Faraj, Abdesslem; Frappier, Francois; Florent, Jean-Claude; Grierson, David S.; Monneret, Claude
Tetrahedron Letters, 1989 , vol. 30, # 15 p. 1955 - 1958
反应条件
1: 85 percent 2: 95 percent / pyridine / 0 °C 3: 98 percent / DBU / 2 h / Heating 4: 85 percent / NaN3 / dimethylformamide / 120 °C 5: Dowex 50(H+) / methanol 6: H2 / Pd/C / methanol View Scheme
参考文献
Maillard, Michel; Faraj, Abdesslem; Frappier, Francois; Florent, Jean-Claude; Grierson, David S.; Monneret, Claude
Tetrahedron Letters, 1989 , vol. 30, # 15 p. 1955 - 1958
反应条件
sodium dihydrogen phosphate dihydrate; disodium hydrogen phosphate dodecahydrate; water; Nitrous oxide γ-irradiation;
参考文献
Dang, Thao P.; Sobczak, Adam J.; Mebel, Alexander M.; Chatgilialoglu, Chryssostomos; Wnuk, Stanislaw F.
Tetrahedron, 2012 , vol. 68, # 27-28 p. 5655 - 5667
反应条件
1: 87 percent / sodium azide / ethane-1,2-diol / 0.75 h / 120 °C 2: 93 percent / sodium borohydride / propan-2-ol / 14 h / 82 °C 3: Dowex 50Wx2 (H+) / methanol; H2O View Scheme
参考文献
Celewicz; Urjasz; Golankiewicz
Nucleosides and Nucleotides, 1993 , vol. 12, # 9 p. 951 - 966
反应条件
1: 1.) lithium azide, 2.) aq. acetic acid / 1.) DMF, 150 deg C, 3 h, 2.) 55 deg C, 4 h 2: 78 percent / Ph3P, pyridine, aq. NH3 View Scheme
参考文献
Zaitseva; Kvasyuk; Vaaks; Barai; Bokut; Zinchenko; Mikhailopulo
Nucleosides and Nucleotides, 1994 , vol. 13, # 1-3 p. 819 - 834
反应条件
glycine buffer T=90.04°C; pH=8.0; Kinetics; Further Variations:pH-values;
参考文献
Ora, Mikko; Murtola, Merita; Aho, Sami; Oivanen, Mikko
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 4 p. 593 - 600
反应条件
sodium tetrahydroborate 1.) EtOH, room temperature, 48 h, 2.) 3 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Jasko; Fedorov; Atrazhev; Mozzherin; Novicov; Bochkarev; Gurskaya; Krayevsky
Nucleosides and Nucleotides, 1995 , vol. 14, # 1-2 p. 23 - 37
反应条件
phosphate buffer; thymidine phosphorylase pH=6.8; 24 h;
参考文献
Panova, Natalya G.; Alexeev, Cyril S.; Polyakov, Konstantin M.; Gavryushov, Sergei A.; Kritzyn, Anatoliy M.; Mikhailov, Sergey N.
Nucleosides, Nucleotides and Nucleic Acids, 2008 , vol. 27, # 12 p. 1211 - 1214
反应条件
phosphate buffer; glutaraldehyde-treated cells of E.coli BM-11; Na-acetate buffer T=50°C; 24 h;
参考文献
Zaitseva; Kvasyuk; Vaaks; Barai; Bokut; Zinchenko; Mikhailopulo
Nucleosides and Nucleotides, 1994 , vol. 13, # 1-3 p. 819 - 834
