2-(2-氨基噻唑-5-基)乙酸合成路线 （共 2 条）
反应条件
1: With sodium hydroxide; water in methanol
T=20°C; 3 h;
2: With hydrogenchloride in water
pH=3.5;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/58752 A1, 2004 ;
Location in patent: Page 123-124 ;
WO 2004/058752 A1
反应条件
1: With sodium hydroxide in tetrahydrofuran; methanol; water
T=20°C;
2: With hydrogenchloride in tetrahydrofuran; methanol; water
pH=3 - 4;
参考文献
ABRAXIS BIOSCIENCE, LLC; TAO, Chunlin; WANG, Qinwei; NALLAN, Laxman; POLAT, Tulay; KORONIAK, Lukasz; DESAI, Neil
Patent: WO2010/144338 A1, 2010 ;
Location in patent: Page/Page column 119 ;
WO 2010/144338 A1
