5-(苄氧基)-2-溴-4-甲氧基苯酚合成路线 （共 8 条）
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
14 h; Heating;
参考文献
Schmidt, Jonathan M.; Tremblay, Gilles B.; Page, Martine; Mercure, Julie; Feher, Miklos; Dunn-Dufault, Robert; Peter, Markus G.; Redden, Peter R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1289 - 1292
反应条件
N-bromosuccinmide in tetrahydrofuran
T=-78°C; 0.583333 h; Inert atmosphere;
参考文献
Nemecek, Gregor; Cudaj, Judith; Podlech, Joachim
European Journal of Organic Chemistry, 2012 , # 20 p. 3863 - 3870
反应条件
1: 83 percent / K2CO3 / acetonitrile / 20 h / 50 °C
2: 85 percent / mCPBA / CH2Cl2 / 14 h / Heating
View Scheme
参考文献
Schmidt, Jonathan M.; Tremblay, Gilles B.; Page, Martine; Mercure, Julie; Feher, Miklos; Dunn-Dufault, Robert; Peter, Markus G.; Redden, Peter R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1289 - 1292
反应条件
1: 83 percent / K2CO3 / acetonitrile / 20 h / 50 °C
2: 85 percent / mCPBA / CH2Cl2 / 14 h / Heating
View Scheme
参考文献
Schmidt, Jonathan M.; Tremblay, Gilles B.; Page, Martine; Mercure, Julie; Feher, Miklos; Dunn-Dufault, Robert; Peter, Markus G.; Redden, Peter R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1289 - 1292
反应条件
1: potassium carbonate / ethanol / 20 h / 20 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C
3: sodium hydroxide / methanol; water / 0.08 h / 20 °C
4: N-bromosuccinmide / tetrahydrofuran / 0.58 h / -78 °C / Inert atmosphere
View Scheme
参考文献
Nemecek, Gregor; Cudaj, Judith; Podlech, Joachim
European Journal of Organic Chemistry, 2012 , # 20 p. 3863 - 3870
反应条件
1: sodium hydroxide / methanol; water / 0.08 h / 20 °C
2: N-bromosuccinmide / tetrahydrofuran / 0.58 h / -78 °C / Inert atmosphere
View Scheme
参考文献
Nemecek, Gregor; Cudaj, Judith; Podlech, Joachim
European Journal of Organic Chemistry, 2012 , # 20 p. 3863 - 3870
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C
2: sodium hydroxide / methanol; water / 0.08 h / 20 °C
3: N-bromosuccinmide / tetrahydrofuran / 0.58 h / -78 °C / Inert atmosphere
View Scheme
参考文献
Nemecek, Gregor; Cudaj, Judith; Podlech, Joachim
European Journal of Organic Chemistry, 2012 , # 20 p. 3863 - 3870
反应条件
1: 5-benzyloxy-2-bromo-4-methoxyphenol With sodium hydride in tetrahydrofuran
0.333333 h;
2: methyl iodide in tetrahydrofuran
T=20°C; 18 h;
参考文献
Schmidt, Jonathan M.; Tremblay, Gilles B.; Page, Martine; Mercure, Julie; Feher, Miklos; Dunn-Dufault, Robert; Peter, Markus G.; Redden, Peter R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1289 - 1292
