1-溴-2,5-二甲氧基-4-苯甲氧基苯合成路线 （共 5 条）
反应条件
1: 5-benzyloxy-2-bromo-4-methoxyphenol With sodium hydride in tetrahydrofuran
T=0°C; 0.333333 h;
2: methyl iodide in tetrahydrofuran
T=20°C; 18 h;
参考文献
Sherris, David
Patent: US2006/257337 A1, 2006 ;
Location in patent: Page/Page column 17 ;
反应条件
1: 5-benzyloxy-2-bromo-4-methoxyphenol With sodium hydride in tetrahydrofuran
0.333333 h;
2: methyl iodide in tetrahydrofuran
T=20°C; 18 h;
参考文献
Schmidt, Jonathan M.; Tremblay, Gilles B.; Page, Martine; Mercure, Julie; Feher, Miklos; Dunn-Dufault, Robert; Peter, Markus G.; Redden, Peter R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1289 - 1292
反应条件
1.1: 83 percent / K2CO3 / acetonitrile / 20 h / 50 °C
2.1: 85 percent / mCPBA / CH2Cl2 / 14 h / Heating
3.1: NaH / tetrahydrofuran / 0.33 h
3.2: 88 percent / tetrahydrofuran / 18 h / 20 °C
View Scheme
参考文献
Schmidt, Jonathan M.; Tremblay, Gilles B.; Page, Martine; Mercure, Julie; Feher, Miklos; Dunn-Dufault, Robert; Peter, Markus G.; Redden, Peter R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1289 - 1292
反应条件
1.1: 85 percent / mCPBA / CH2Cl2 / 14 h / Heating
2.1: NaH / tetrahydrofuran / 0.33 h
2.2: 88 percent / tetrahydrofuran / 18 h / 20 °C
View Scheme
参考文献
Schmidt, Jonathan M.; Tremblay, Gilles B.; Page, Martine; Mercure, Julie; Feher, Miklos; Dunn-Dufault, Robert; Peter, Markus G.; Redden, Peter R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1289 - 1292
反应条件
1.1: 83 percent / K2CO3 / acetonitrile / 20 h / 50 °C
2.1: 85 percent / mCPBA / CH2Cl2 / 14 h / Heating
3.1: NaH / tetrahydrofuran / 0.33 h
3.2: 88 percent / tetrahydrofuran / 18 h / 20 °C
View Scheme
参考文献
Schmidt, Jonathan M.; Tremblay, Gilles B.; Page, Martine; Mercure, Julie; Feher, Miklos; Dunn-Dufault, Robert; Peter, Markus G.; Redden, Peter R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1289 - 1292
