4-(2-吗啉-4-乙氧基)苯胺合成路线 （共 12 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol; water T=20°C; P=2999.46 Torr; 1 h;
参考文献
Tietze, Lutz F.; Major, Felix
European Journal of Organic Chemistry, 2006 , # 10 p. 2314 - 2321
反应条件
water; trifluoroacetic acid in dichloromethane T=20°C; 2 h;
参考文献
PHARMACOPEIA, INC.
Patent: WO2007/104053 A2, 2007 ;
Location in patent: Page/Page column 43 ;
WO 2007/104053 A2
反应条件
sodium hydroxide in N,N-dimethyl-formamide T=20°C; 23.5 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2007/71752 A2, 2007 ;
Location in patent: Page/Page column 68 ;
WO 2007/071752 A2
反应条件
1: 7.2 g / toluene / 24 h / Heating 2: 100 percent / H2 / Pd/C / ethanol; H2O / 1 h / 20 °C / 2999.46 Torr View Scheme
参考文献
Chabrier et al.
Bulletin de la Societe Chimique de France, 1955 , p. 1353,1358
反应条件
in N-methyl-acetamide; ice-water; mineral oil
参考文献
Hoffmann-La Roche Inc.
Patent: US5128470 A1, 1992 ;
反应条件
1: 7.2 g / toluene / 24 h / Heating 2: 100 percent / H2 / Pd/C / ethanol; H2O / 1 h / 20 °C / 2999.46 Torr View Scheme
参考文献
Tietze, Lutz F.; Major, Felix
European Journal of Organic Chemistry, 2006 , # 10 p. 2314 - 2321
反应条件
1: 82.4 percent / NaH / dimethylformamide / 1 h / 0 °C 2: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature View Scheme
参考文献
Sohda; Mizuno; Imamiya; Sugiyama; Fujita; Kawamatsu
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3580 - 3600
反应条件
1: 82.4 percent / NaH / dimethylformamide / 1 h / 0 °C 2: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature View Scheme
参考文献
Sohda; Mizuno; Imamiya; Sugiyama; Fujita; Kawamatsu
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3580 - 3600
反应条件
1: sodium ethylate; ethanol 2: palladium/charcoal; ethanol / Hydrogenation View Scheme
参考文献
Pan, Xiaoyan; Wang, Fang; Zhang, Yanmin; Gao, Hongping; Hu, Zhigang; Wang, Sicen; Zhang, Jie
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 9 p. 2527 - 2534
反应条件
1: aqueous K2CO3; xylene 2: palladium/charcoal; ethanol / Hydrogenation View Scheme
参考文献
Pan, Xiaoyan; Wang, Fang; Zhang, Yanmin; Gao, Hongping; Hu, Zhigang; Wang, Sicen; Zhang, Jie
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 9 p. 2527 - 2534
