3-氨基-4,6-二甲基-噻吩并[2,3-b]吡啶-2-甲腈合成路线 （共 5 条）
反应条件
potassium hydroxide in water; N,N-dimethyl-formamide
T=20 - 50°C; 0.75 h;
参考文献
VANDERBILT UNIVERSITY; CONN, P., Jeffrey; LINDSLEY, Craig, W.; WOOD, Michael, R.; HOPKINS, Corey, R.; SALOVICH, James, M.; MELANCON, Bruce, J.
Patent: WO2013/40534 A1, 2013 ;
Location in patent: Paragraph 00690 ;
反应条件
sodium ethanolate in ethanol
0.25 h; Heating;
参考文献
Hassan, Kh. M.; El-Dean, A. M. Kamal; Youssef, M. S. K.; Atta, F. M.; Abbady, M. S.
Phosphorus, Sulfur and Silicon and the Related Elements, 1990 , vol. 47, # 1 + 2 p. 181 - 189
反应条件
1: 84 percent / sodium acetate / ethanol / 0.5 h / Heating
2: 92 percent / NaOC2H5 / ethanol / 0.25 h / Heating
View Scheme
参考文献
Hassan, Kh. M.; El-Dean, A. M. Kamal; Youssef, M. S. K.; Atta, F. M.; Abbady, M. S.
Phosphorus, Sulfur and Silicon and the Related Elements, 1990 , vol. 47, # 1 + 2 p. 181 - 189
参考文献
Shevdov,V.I. et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1979 , vol. 15, p. 1070 - 1074
Khimiya Geterotsiklicheskikh Soedinenii, 1979 , vol. 15, p. 1331 - 1335
反应条件
1: Na2CO3
2: POCl3
View Scheme
参考文献
Shevdov,V.I. et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1979 , vol. 15, p. 1070 - 1074
Khimiya Geterotsiklicheskikh Soedinenii, 1979 , vol. 15, p. 1331 - 1335
