2,4-二甲氧基-5-碘嘧啶合成路线 （共 11 条）
反应条件
N-chloro-succinimide; sodium iodide in hexane; chloroform; acetic acid; acetone
参考文献
Bio-Rad Laboratories Inc.
Patent: US2003/191074 A1, 2003 ;
反应条件
iodine; potassium iodide in water T=60°C; 0.75 h;
参考文献
Skul'ski, L.; Kuyava, A.; Vrochin'ski, P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1989 , vol. 25, # 2 p. 205 - 208
Khimiya Geterotsiklicheskikh Soedinenii, 1989 , # 2 p. 249 - 252
反应条件
N-iodo-succinimide; trifluoroacetic acid; trifluoroacetic anhydride 8 h; Heating;
参考文献
Das, Biswajit; Kundu, Nitya G.
Synthetic Communications, 1988 , vol. 18, # 8 p. 855 - 868
反应条件
iodine in water Heating;
参考文献
Skul'ski, L.; Kuyava, A.; Vrochin'ski, P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1989 , vol. 25, # 2 p. 205 - 208
Khimiya Geterotsiklicheskikh Soedinenii, 1989 , # 2 p. 249 - 252
反应条件
1: With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; CdCl2*TMEDA in tetrahydrofuran; hexane T=0 - 20°C; Inert atmosphere; 2: With iodine in tetrahydrofuran; hexane Inert atmosphere; regioselective reaction;
参考文献
Snegaroff, Katia; L'Helgoual'ch, Jean-Martial; Bentabed-Ababsa, Ghenia; Nguyen, Tan Tai; Chevallier, Floris; Yonehara, Mitsuhiro; Uchiyama, Masanobu; Derdour, Aicha; Mongin, Florence
Chemistry - A European Journal, 2009 , vol. 15, # 39 p. 10280 - 10290
反应条件
in methanol Substitution;
参考文献
Kundu, Nitya G.; Khan, M. Wahab
Tetrahedron, 2000 , vol. 56, # 27 p. 4777 - 4792
反应条件
sodium methylate; trichlorophosphate
参考文献
Goudgaon, Naganna M.; El-Kattan, Yahya A.; Xia, Xiaoyang; McAtee, Jeff; Soria, Jose; Wey, Shiow-Jyi; Liotta, Dennis C.; Schinazi, Raymond F.
Nucleosides and Nucleotides, 1997 , vol. 16, # 12 p. 2133 - 2150
参考文献
Skul'ski, L.; Kuyava, A.; Vrochin'ski, P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1989 , vol. 25, # 2 p. 205 - 208
Khimiya Geterotsiklicheskikh Soedinenii, 1989 , # 2 p. 249 - 252
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in triethylamine
参考文献
Goudgaon, Naganna M.; El-Kattan, Yahya A.; Xia, Xiaoyang; McAtee, Jeff; Soria, Jose; Wey, Shiow-Jyi; Liotta, Dennis C.; Schinazi, Raymond F.
Nucleosides and Nucleotides, 1997 , vol. 16, # 12 p. 2133 - 2150
反应条件
triethylamine; copper(l) iodide in N,N-dimethyl-formamide
T=35°C; 48 h; Yield given. Yields of byproduct given;
参考文献
Pal, Manojit; Kundu, Nitya G.
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 5 p. 449 - 451
