1-(2-氯乙基)-2,3-二氢苯并咪唑-2-酮合成路线 （共 2 条）
反应条件
1: 2-Hydroxy-1H-benzimidazole With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.333333 h; 2: 1-chloro-2-iodo-ethane in N,N-dimethyl-formamide T=20°C; 1.5 h;
参考文献
Kelly, Nicholas Michael; Koch, Kristian Norup; Tolf, Bo-Ragnar
Patent: US2004/67931 A1, 2004 ;
Location in patent: Page/Page column 22 ;
反应条件
potassium hydroxide; tetrabutylammomium bromide 1.) H2O, room temp., 48 h, 2.) 100 deg C, 4 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Diez-Barra, Enrique; Dotor, Julio; De La Hoz, Antonio; Foces-Foces, Concepcion; Enjalbal, Christine; Aubagnac, Jean Louis; Claramunt, Rosa Maria; Elguero, Jose
Tetrahedron, 1997 , vol. 53, # 22 p. 7689 - 7704
