(2-氧代-2-哌嗪-1-乙基)-氨基甲酸叔丁酯合成路线 （共 5 条）
反应条件
1: BOC-glycine With benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine in dichloromethane
0.0833333 h;
2: piperazine in dichloromethane
20 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/70865 A2, 2007 ;
Location in patent: Page/Page column 25; 45-46 ;
反应条件
1: BOC-glycine With HATU in N,N-dimethyl acetamide
T=20°C; 0.333333 h;
2: piperazine in N,N-dimethyl acetamide
T=20°C; 17 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/32033 A1, 2008 ;
Location in patent: Page/Page column 89-90 ;
WO 2008/032033 A1
反应条件
ammonium formate; palladium on activated charcoal in methanol
8 h; Heating;
参考文献
Scapecchi, Serena; Martini, Elisabetta; Manetti, Dina; Ghelardini, Carla; Martelli, Cecilia; Dei, Silvia; Galeotti, Nicoletta; Guandalini, Luca; Romanelli, Maria Novella; Teodori, Elisabetta
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 1 p. 71 - 85
反应条件
1.1: N-hydroxysuccinimide; N,N'-dicyclohexylcarbodiimide / CH2Cl2 / 21 h / 0 - 20 °C
1.2: 70 percent / CH2Cl2 / 24 h / 20 °C
2.1: 75 percent / HCOONH4 / Pd/C / methanol / 8 h / Heating
View Scheme
参考文献
Scapecchi, Serena; Martini, Elisabetta; Manetti, Dina; Ghelardini, Carla; Martelli, Cecilia; Dei, Silvia; Galeotti, Nicoletta; Guandalini, Luca; Romanelli, Maria Novella; Teodori, Elisabetta
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 1 p. 71 - 85
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4921855 A1, 1990 ;
