1: With lithium aluminium tetrahydride in tetrahydrofuran
T=-70 - 50°C; 23 h;
2: With sodium hydroxide; water in tetrahydrofuran
T=-70°C;
参考文献
Holloway, M. Katharine; Liverton, Nigel J.; Ludmerer, Steven W.; McCauley, John A.; Olsen, David B.; Rudd, Michael T.; Vacca, Joseph P.; McIntyre, Charles J.
Patent: US2007/27071 A1, 2007 ;
Location in patent: Page/Page column 78 ;
US 20070027071 A1
N-ethyl-N,N-diisopropylamine in dichloromethane
T=0°C; 2 h;
参考文献
Holloway, M. Katharine; Liverton, Nigel J.; Ludmerer, Steven W.; McCauley, John A.; Olsen, David B.; Rudd, Michael T.; Vacca, Joseph P.; McIntyre, Charles J.
Patent: US2007/27071 A1, 2007 ;
Location in patent: Page/Page column 78 ;
US 20070027071 A1
1: 3-vinylpropionic acid With oxalyl dichloride in dichloromethane
T=20°C;
2: methylamine With pyridine in dichloromethane
T=0 - 20°C; Further stages.;
参考文献
Tellitu, Imanol; Urrejola, Andrea; Serna, Sonia; Moreno, Isabel; Herrero, M. Teresa; Dominguez, Esther; SanMartin, Raul; Correa, Arkaitz
European Journal of Organic Chemistry, 2007 , # 3 p. 437 - 444
