2-(吡啶-2-基)-2-丙胺合成路线 (共 4 条)
反应条件
1: methyllithium With cerium(III) chloride in tetrahydrofuran; diethyl ether T=-76 - -60°C; 2: 2-pyridine carbonitrile in tetrahydrofuran; diethyl ether T=-76 - 15°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2009/131814 A2, 2009 ;
Location in patent: Page/Page column 43 ;
WO 2009/131814 A2
反应条件
1: in toluene T=0 - 100°C; 2: With hydrogenchloride; water in toluene T=0°C; 3: With sodium hydroxide in water
参考文献
Myriad Genetics, Incorporated
Patent: US2008/207573 A1, 2008 ;
Location in patent: Page/Page column 80; 87 ;
反应条件
1: methyllithium With cerium(III) chloride in tetrahydrofuran; diethyl ether 0.833333 h; Cooling with acetone-dry ice; 2: 2-pyridine carbonitrile in tetrahydrofuran; diethyl ether T=20°C; 5 h; Cooling with acetone-dry ice; 3: With ammonia; water in tetrahydrofuran; diethyl ether T=0°C;
参考文献
MITSUBISHI TANABE PHARMA CORPORATION
Patent: WO2008/4698 A2, 2008 ;
Location in patent: Page/Page column 129-130 ;
反应条件
trifluoroacetic acid in dichloromethane T=20°C;
参考文献
Jaudzems, Kristaps; Tars, Kaspars; Maurops, Gundars; Ivdra, Natalija; Otikovs, Martins; Leitans, Janis; Kanepe-Lapsa, Iveta; Domraceva, Ilona; Mutule, Ilze; Trapencieris, Peteris; Blackman, Michael J.; Jirgensons, Aigars
ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 4 p. 373 - 377