3-甲基-1H-吲哚-2-甲醛合成路线 （共 33 条）
反应条件
1: in methanol
T=20°C; 1 h;
2: With sodium cyanoborohydride; acetic acid in methanol
36 h;
参考文献
GLAXOSMITHKLINE S.P.A.; CONSONNI, Alessandra
Patent: WO2005/5411 A1, 2005 ;
Location in patent: Page/Page column 62 ;
WO 2005/005411 A1
反应条件
1: 97 percent / NaH / tetrahydrofuran / 1 h / 20 °C
2: EtONa / ethanol / 7 h / -15 °C
3: toluene / 14 h / Heating
View Scheme
参考文献
Papamicael, Cyril; Dupas, Georges; Queguiner, Guy; Bourguignon, Jean
Heterocycles, 1998 , vol. 49, # 1 p. 361 - 373
反应条件
1: in methanol; ethanol
5 h;
2: With sodium tetrahydroborate in methanol; ethanol
T=0 - 20°C;
3: With water in methanol; ethanol
T=0°C;
参考文献
AFFINIUM PHARMACEUTICALS, INC.
Patent: WO2007/53131 A2, 2007 ;
Location in patent: Page/Page column 166-167 ;
WO 2007/053131 A2
