3-碘-2-甲基苯甲酸甲酯合成路线 （共 4 条）
反应条件
copper(l) iodide in DMF (N,N-dimethyl-formamide) T=80°C; 16 h;
参考文献
Kuroki, Yoshiaki; Ueno, Hitoshi; Katsube, Tetsushi; Kawaguchi, Tetsuo; Okanari, Eiji; Ikuta, Takashi
Patent: US2003/216571 A1, 2003 ;
Location in patent: Page/Page column 62-63 ;
反应条件
1: With sulfuric acid; sodium nitrite
T=0°C; 1 h;
2: With potassium iodide
T=0°C; 1 h;
参考文献
Bressy, Cyril; Alberico, Dino; Lautens, Mark
Journal of the American Chemical Society, 2005 , vol. 127, # 38 p. 13148 - 13149
反应条件
thionyl chloride
T=0°C; 3 h; Heating / reflux;
参考文献
PFIZER INC.
Patent: WO2006/117669 A1, 2006 ;
Location in patent: Page/Page column 41; 108 ;
反应条件
triethylamine in tetrahydrofuran
T=0 - 20°C; 0.833333 h; Product distribution / selectivity;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2008/16184 A1, 2008 ;
Location in patent: Page/Page column 120-121 ;
