乙基2-(苯甲酰基氨基)-4,5,6,7-四氢-1-苯并噻吩-3-羧酸酯合成路线 （共 4 条）
反应条件
1,2,2-trichloro-1,1,2-trichloro-ethane; triethylamine; triphenylphosphine in dichloromethane
2 h; Heating;
参考文献
Achakzi, Darwizah; Ertas, Muemtaz; Appel, Rolf; Wamhoff, Heinrich
Chemische Berichte, 1981 , vol. 114, # 9 p. 3188 - 3194
反应条件
1: 39.7 percent / K2Cr2O7 / aq. acetic acid
2: KOH / methanol / 1 h / 20 °C
View Scheme
参考文献
Kharizomenova, I. A.; Kapustina, M. V.; Grinev, A. N.; Sheinker, Yu. N.; Alekseeva, L. M.; Kuleshova, E. F.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 12 p. 1339 - 1342
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , # 12 p. 1626 - 1629
反应条件
1: 39.7 percent / K2Cr2O7 / aq. acetic acid
2: KOH / methanol / 1 h / 20 °C
3: 1. NaNO2, conc. HCl; 2. copper acetate / 1. dioxane, -7 to -10 deg C, 20 min; 2. dioxane, ethanol, 70 deg C, 30 min
4: 45.9 percent / NaOH; aq. HCl / ethanol / 0.33 h / Heating
View Scheme
参考文献
Kharizomenova, I. A.; Kapustina, M. V.; Grinev, A. N.; Sheinker, Yu. N.; Alekseeva, L. M.; Kuleshova, E. F.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 12 p. 1339 - 1342
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , # 12 p. 1626 - 1629
反应条件
sodium hydroxide in methanol
参考文献
Shvedov,V.I. et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1973 , vol. 9, p. 1469 - 1472
Khimiya Geterotsiklicheskikh Soedinenii, 1973 , vol. 9, p. 1624 - 1627
