N-三氟乙酰氨基-1,4-二-p-硝基苯甲酰柔胺合成路线 （共 3 条）
反应条件
1: 1.) Trimethylsilyl triflate, 4A mol. sieves / 1.) CH2Cl2-Et2O (3:1), -40 deg C than -3 - -5 deg C, 1h; 2.) -15 deg C, 2.5 hrs 2: 0.1 mol dm-3 NaOH / CH2Cl2; methanol / 0.5 h / 0 °C 3: 77 percent / 0.1 mol dm-3 NaOH / H2O / 0.5 h / Ambient temperature View Scheme
参考文献
Kimura, Yoshikazu; Suzuki, Michiyo; Matsumoto, Teruyo; Abe, Rumiko; Terashima, Shiro
Chemistry Letters, 1984 , p. 501 - 504
反应条件
1: 22 percent / TMSOTf, molecular sieves 4 Angstroem / CH2Cl2; diethyl ether / 7.5 h
2: 41 percent / aq. 80percent AcOH / 40 h / 45 °C
3: 82 percent / 0.1N NaOH / CH2Cl2; methanol / 0.33 h / 0 °C
4: 95 percent / 0.1N NaOH / 0.33 h / Ambient temperature
View Scheme
参考文献
Tamura; Akai; Kishimoto; et al.
Tetrahedron Letters, 1987 , vol. 28, # 39 p. 4583 - 4586
反应条件
2: NaOH / methanol / 0.33 h / 0 - 5 °C
3: d-10-camphorsulfonic acid / tetrahydrofuran / 2 h / Ambient temperature
4: NaOH / 0.75 h / Ambient temperature
5: HCl / methanol / 15 h / Ambient temperature
View Scheme
参考文献
Kimura, Yoshikazu; Suzuki, Michiyo; Terashima, Shiro
Chemistry Letters, 1984 , p. 2113 - 2116
