5-乙酰基-6-甲基-2-氧代-1,2-二羟基吡啶-3-甲腈合成路线 （共 22 条）
反应条件
sodium methylate in methanol; water; acetic acid
参考文献
Sterling Drug Inc.
Patent: US4469699 A1, 1984 ;
反应条件
sodium methylate in methanol; water
参考文献
Sterling Drug Inc.
Patent: US4469699 A1, 1984 ;
反应条件
sodium hydride in N,N-dimethyl-formamide 24 h; Ambient temperature;
参考文献
Abu-Shanab; Redhouse; Thompson; Wakefield
Synthesis, 1995 , # 5 p. 557 - 560
参考文献
Merrell Dow Pharmaceuticals Inc.
Patent: US4568751 A1, 1986 ;
反应条件
in ethanol 24 h; Ambient temperature;
参考文献
Mosti, Luisa; Schenone, Pietro; Menozzi, Giulia
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1503 - 1509
反应条件
in ethanol 24 h; Ambient temperature;
参考文献
Mosti, Luisa; Schenone, Pietro; Menozzi, Giulia
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1503 - 1509
反应条件
piperidine in ethanol Heating;
参考文献
Attia, Adel M.; Elgemeie, Galal H.; Alnaimi, Ibrahim S.
Nucleosides and Nucleotides, 1998 , vol. 17, # 8 p. 1355 - 1363
反应条件
1: Ambient temperature 2: 1) sodium hydride / 1) mineral oil, tetrahydrofuran, 50 deg C, 2) tetrahydrofuran, 50 deg C, overnight View Scheme
参考文献
Jones Jr.; Schnettler; Huber
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 3 p. 511 - 518
反应条件
sodium hydride 1) mineral oil, tetrahydrofuran, 50 deg C, 2) tetrahydrofuran, 50 deg C, overnight; Yield given. Multistep reaction;
参考文献
Jones Jr.; Schnettler; Huber
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 3 p. 511 - 518
反应条件
hydrogenchloride 8 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, p. 1503 - 1509
