7,16-二[(4-甲基苯基)磺酰基]-1,4,10,13-四氧杂-7,16-二氮杂环十八烷合成路线 （共 18 条）
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in benzene
8 h; Heatingother bases, under liquid-liquid PT-conditions, reaction with further p-toluenesulphonate ester of diols;
参考文献
Singh, Paramjit; Jain, Anupa
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 790 - 792
反应条件
2: 97 percent / triethylamine, 4-dimethylaminopyridine (DMAP) / CH2Cl2 / 2 h / Ambient temperature
3: 1.) sodium hydride / 1.) DMF, 80 deg C, 2.5 h, 2.) DMF, 80 deg C, 24 h
View Scheme
参考文献
Boerjesson, L.; Welch, C. J.
Acta Chemica Scandinavica, 1991 , vol. 45, # 6 p. 621 - 626
反应条件
1: 97 percent / triethylamine, 4-dimethylaminopyridine (DMAP) / CH2Cl2 / 2 h / Ambient temperature
2: 1.) sodium hydride / 1.) DMF, 80 deg C, 2.5 h, 2.) DMF, 80 deg C, 24 h
View Scheme
参考文献
Boerjesson, L.; Welch, C. J.
Acta Chemica Scandinavica, 1991 , vol. 45, # 6 p. 621 - 626
反应条件
1: 70 percent / triethylamine, 4-dimethylaminopyridine (DMAP) / CH2Cl2 / 2 h / Ambient temperature
3: 97 percent / triethylamine, 4-dimethylaminopyridine (DMAP) / CH2Cl2 / 2 h / Ambient temperature
4: 1.) sodium hydride / 1.) DMF, 80 deg C, 2.5 h, 2.) DMF, 80 deg C, 24 h
View Scheme
参考文献
Boerjesson, L.; Welch, C. J.
Acta Chemica Scandinavica, 1991 , vol. 45, # 6 p. 621 - 626
反应条件
sodium hydride
1.) THF, mineral oil, reflux, 2 h, 2.) THF, reflux, 48 h; Yield given. Multistep reaction;
参考文献
Vries, Erik F. J. de; Steenwinkel, Pablo; Brussee, Johannes; Kruse, Chris G.; Gen, Arne van der
Journal of Organic Chemistry, 1993 , vol. 58, # 16 p. 4315 - 4325
反应条件
sodium hydride
1.) DMF, 80 deg C, 2.5 h, 2.) DMF, 80 deg C, 24 h; Yield given. Multistep reaction;
参考文献
Boerjesson, L.; Welch, C. J.
Acta Chemica Scandinavica, 1991 , vol. 45, # 6 p. 621 - 626
反应条件
sodium hydroxide; tetra-(n-butyl)ammonium iodide in toluene
Heating;
参考文献
Lukyanenko, Nikolai G.; Basok, Stepan S.; Filonova, Lyubov K.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 3141 - 3148
参考文献
Pappalardo, Sebastiano; Bottino, Francesco; Grazia, Michele Di; Finocchiaro, Paolo; Mamo, Antonino
Heterocycles, 1985 , vol. 23, # 8 p. 1881 - 1884
