2,4-二甲氧基5-嘧啶-甲醛合成路线 （共 12 条）
反应条件
sodium hydroxide; water in 1,4-dioxane T=25°C; 1.5 h;
参考文献
Kumar; Knaus; Wiebe; Allen; Tempest
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 5 p. 557 - 562
反应条件
Potassium peroxomonosulfate; ethylenediaminetetraacetic acid disodium salt; sodium carbonate in water; acetone T=25°C; 2 h;
参考文献
Kumar; Knaus; Wiebe; Allen; Tempest
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 5 p. 557 - 562
反应条件
2,6-dimethylpyridine; dipotassium peroxodisulfate; sulfuric acid; copper(II) sulfate in water; acetonitrile T=80°C; 1 h;
参考文献
Coutouli-Argyropoulou, Evdoxia; Zachariadou, Christina
Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 6 p. 1135 - 1142
反应条件
in diethyl ether; hexane; water; Nalco silica sol 1060
参考文献
University of Birmingham
Patent: US5356882 A1, 1994 ;
参考文献
Baxter, Andrew; Brough, Stephen; Faull, Alan; Johnstone, Craig; McInally, Thomas
Patent: US2002/107252 A1, 2002 ;
反应条件
1: 82 percent / methanol / 52 h / 25 °C 2: 66.8 percent / I2, KIO3, 5 N H2SO4 / H2O; acetonitrile / 4 h / 60 °C 3: 80 percent / NaOH, water / dioxane / 1.5 h / 25 °C View Scheme
参考文献
Kumar; Knaus; Wiebe; Allen; Tempest
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 5 p. 557 - 562
反应条件
1: 46 percent / POCl3, N,N-diethylanilinemine / 0.5 h / Heating 2: 82 percent / methanol / 52 h / 25 °C 3: 66.8 percent / I2, KIO3, 5 N H2SO4 / H2O; acetonitrile / 4 h / 60 °C 4: 80 percent / NaOH, water / dioxane / 1.5 h / 25 °C View Scheme
参考文献
Kumar; Knaus; Wiebe; Allen; Tempest
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 5 p. 557 - 562
反应条件
in diethyl ether T=0°C; Yield given;
参考文献
Wada, Akimori; Yamamoto, Junpei; Kanatomo, Shoichi
Heterocycles, 1987 , vol. 26, # 3 p. 585 - 589
反应条件
n-butyllithium 1.) toluene, hexane, -78 deg C, 10 min; Yield given. Multistep reaction;
参考文献
Bobek; Kavai; De Clercq
Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1494 - 1497
反应条件
2,2,6,6-tetramethylpiperidinyl-lithium 1.) ether, 0 deg C, 10 min 2.) ether, r.t.; Yield given. Multistep reaction;
参考文献
Wada; Yamamoto; Hamaoka; Ohki; Nagai; Kanatomo
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 6 p. 1831 - 1835
