4-氯-2-甲基-6-苯基-5H-吡咯并[3,2-d]嘧啶合成路线 （共 5 条）
反应条件
potassium carbonate in water
T=120°C; 4 h;
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
N,N-diethylaniline; trichlorophosphate in water; ethyl acetate
参考文献
Amgen Inc.
Patent: US6187777 B1, 2001 ;
反应条件
N,N-diethylaniline; trichlorophosphate in 1,2-dichloro-ethane
3 h; Heating;
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
1.1: NaOEt / ethanol / 0.5 h / 20 °C
1.2: 44 percent / ethanol / 20 °C
2.1: 15 percent / NaOEt / 0.33 h / 360 °C
3.1: 44 percent / POCl3; N,N-diethylaniline / 1,2-dichloro-ethane / 3 h / Heating
View Scheme
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
1: 15 percent / NaOEt / 0.33 h / 360 °C
2: 44 percent / POCl3; N,N-diethylaniline / 1,2-dichloro-ethane / 3 h / Heating
View Scheme
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
