1.1: sodium hydrogencarbonate / water; toluene / 0.5 h / Large scale reaction 1.2: 1.5 h / Reflux 2.1: tin(IV) chloride / dichloromethane / 1 h / 0 - 25 °C 3.1: tetrabutylammomium bromide; potassium iodide / N,N-dimethyl-formamide / 14 h / 85 °C 4.1: methylamine / water; isopropyl alcohol / 1 h / 75 °C 5.1: isopropyl alcohol / 1.5 h / 5 - 65 °C / Large scale reaction 6.1: sodium hydrogencarbonate / dichloromethane; water / 0.5 h 7.1: triethylamine / toluene / 0.5 h / -5 - 5 °C View Scheme

1.1: sodium hydrogencarbonate / water; toluene / 0.5 h / Large scale reaction 1.2: 1.5 h / Reflux 2.1: tin(IV) chloride / dichloromethane / 1 h / 0 - 25 °C 3.1: tetrabutylammomium bromide; potassium iodide / N,N-dimethyl-formamide / 14 h / 85 °C 4.1: methylamine / water; isopropyl alcohol / 1 h / 75 °C 5.1: isopropyl alcohol / 1.5 h / 5 - 65 °C / Large scale reaction 6.1: sodium hydrogencarbonate / dichloromethane; water / 0.5 h View Scheme