4-甲氧基-5,6,7,8-四氢-[1,3]二氧并[4,5-g]异喹啉合成路线 （共 9 条）
反应条件
1: 92 percent / KMnO4 / tetrahydrofuran / 0.42 h 2: 98 percent / ethanol View Scheme
参考文献
Fleischhacker, Wilhelm; Richter, Bernd; Urban, Ernst
Monatshefte fuer Chemie, 1989 , vol. 120, p. 765 - 770
反应条件
potassium permanganate in tetrahydrofuran
0.416667 h;
参考文献
Fleischhacker, Wilhelm; Richter, Bernd; Urban, Ernst
Monatshefte fuer Chemie, 1989 , vol. 120, p. 765 - 770
反应条件
methanol; sodium tetrahydroborate
T=0 - 20°C; 18 h;
参考文献
PAIN THERAPEUTICS, INC.
Patent: WO2010/51374 A1, 2010 ;
Location in patent: Page/Page column 127 ;
反应条件
1: 98 percent / H2 / 5percent Pd-C / methanol / 2 h / Ambient temperature
2: 1) 6N HCl, 2) H2 / 2) 5percent Pd-C / 1)r.t., 4 d, 2) r.t.
View Scheme
参考文献
Shirasaka, Tadashi; Takuma, Yuki; Shimpuku, Tetsuro; Imaki, Naoshi
Journal of Organic Chemistry, 1990 , vol. 55, # 12 p. 3767 - 3771
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal
1)r.t., 4 d, 2) r.t.; Yield given. Multistep reaction;
参考文献
Shirasaka, Tadashi; Takuma, Yuki; Shimpuku, Tetsuro; Imaki, Naoshi
Journal of Organic Chemistry, 1990 , vol. 55, # 12 p. 3767 - 3771
反应条件
lithium aluminium tetrahydride in 1,4-dioxane
参考文献
Korbonits,D.; Harsanyi,K.
Chemische Berichte, 1966 , vol. 99, p. 267 - 272
反应条件
sodium tetrahydroborate; trifluoroacetic acid in dichloromethane
Ambient temperature;
参考文献
Simig, Gy.; Schlosser, M.
ACH - Models in Chemistry, 1994 , vol. 131, # 2 p. 217 - 228
反应条件
1: Ni(OAc)2, piperidine / toluene
2: LiAlH4 / dioxane
View Scheme
参考文献
Korbonits,D.; Harsanyi,K.
Chemische Berichte, 1966 , vol. 99, p. 267 - 272
反应条件
(i) H2, Pd-C, EtOH, (ii) AcOH; Multistep reaction;
参考文献
Beke,D.; Eckhart,E.
Chemische Berichte, 1962 , vol. 95, p. 1059 - 1065
