2-氧代环己烷羧酸二甲酰胺合成路线 （共 5 条）
反应条件
1: With sodium chloride in tetrahydrofuran; water
T=4°C; 2 h;
2: With sodium hydroxide in tetrahydrofuran; water
pH=7 - 8;
参考文献
Gruenenthal GmbH
Patent: US2011/295038 A1, 2011 ;
Location in patent: Page/Page column 17-19 ;
反应条件
dichloro bis(acetonitrile) palladium(II); ytterbium(III) triflate in 1,4-dioxane
T=50°C; 36 h;
参考文献
Yang, Dan; Li, Jin-Heng; Gao, Qiang; Yan, Yi-Long
Organic Letters, 2003 , vol. 5, # 16 p. 2869 - 2871
反应条件
in ethanol
T=110°C; 12 h;
参考文献
Vifor (International) AG; Bark, Thomas; Buhr, Wilm; Burckhardt, Susanna; Burgert, Michael; Canclini, Camillo; Dürrenberger, Franz; Funk, Felix; Geisser, Peter; Kalogerakis, Aris; Mayer, Simona; Philipp, Erik; Reim, Stefan; Sieber, Diana; Schmitt, Jörg; Schwarz, Katrin
Patent: US2013/109662 A1, 2013 ;
Location in patent: Paragraph 0542; 0543; 0544; 0545; 0546; 0547 ;
参考文献
Bodnarchuk,N.D. et al.
Zhurnal Organicheskoi Khimii, 1974 , vol. 10, # 4 p. 735 - 740,740 - 744
反应条件
(i) dioxane, (ii) aq. NaOH; Multistep reaction;
参考文献
Nakai,T.; Okawara,M.
Bulletin of the Chemical Society of Japan, 1970 , vol. 43, p. 3528 - 3534
