5,6-二甲氧基-1,2,3,4-四氢萘-2-酮合成路线 （共 21 条）
反应条件
1: 89 percent / 2,4,6-collidine; copper(I)iodide / methanol / 19 h / Heating
2: 76 percent / Na; EtOH / Heating
View Scheme
参考文献
Taber, Douglass F.; Neubert, Timothy D.; Rheingold, Arnold L.
Journal of the American Chemical Society, 2002 , vol. 124, # 42 p. 12416 - 12417
反应条件
1: DBU
2: H2 / Pd/C
3: 1.) n-BuLi
4: TFA
5: Raney-Ni
View Scheme
参考文献
Campiani, Giuseppe; Kozikowski, Alan P.; Wang, Shaomeng; Ming, Liu; Nacci, Vito; Saxena, Ashima; Doctor, Bhupendra P.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 11 p. 1413 - 1418
反应条件
1: NaBH4 / aq. ethanol
2: KHSO4
3: (i) MCPBA, CHCl3, (ii) aq. HCl, EtOH
View Scheme
参考文献
Cannon; O'Donnell; Rosazza; Hoppin
Journal of Medicinal Chemistry, 1974 , vol. 17, # 5 p. 565 - 568
反应条件
1: H2 / Pd/C
2: 1.) n-BuLi
3: TFA
4: Raney-Ni
View Scheme
参考文献
Campiani, Giuseppe; Kozikowski, Alan P.; Wang, Shaomeng; Ming, Liu; Nacci, Vito; Saxena, Ashima; Doctor, Bhupendra P.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 11 p. 1413 - 1418
反应条件
1: 94 percent / SOCl2 / benzene / 4 h / Heating
2: 99 percent / diethyl ether / 1) 5 deg C to rt, 2) rt, overnight
3: 1) Rh(OAc)2, 2) CF3COOH / 1) CH2Cl2, reflux, 10 min, 2) reflux, 15 min
View Scheme
参考文献
Copinga, Swier; Dijkstra, Durk; Vries, Jan B. de; Grol, Cor J.; Horn, Alan S.
Recueil des Travaux Chimiques des Pays-Bas, 1993 , vol. 112, # 2 p. 137 - 142
反应条件
1: 99 percent / diethyl ether / 1) 5 deg C to rt, 2) rt, overnight
2: 1) Rh(OAc)2, 2) CF3COOH / 1) CH2Cl2, reflux, 10 min, 2) reflux, 15 min
View Scheme
参考文献
Copinga, Swier; Dijkstra, Durk; Vries, Jan B. de; Grol, Cor J.; Horn, Alan S.
Recueil des Travaux Chimiques des Pays-Bas, 1993 , vol. 112, # 2 p. 137 - 142
反应条件
1: KHSO4
2: (i) MCPBA, CHCl3, (ii) aq. HCl, EtOH
View Scheme
参考文献
Cannon; O'Donnell; Rosazza; Hoppin
Journal of Medicinal Chemistry, 1974 , vol. 17, # 5 p. 565 - 568
反应条件
1: TFA
2: Raney-Ni
View Scheme
参考文献
Campiani, Giuseppe; Kozikowski, Alan P.; Wang, Shaomeng; Ming, Liu; Nacci, Vito; Saxena, Ashima; Doctor, Bhupendra P.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 11 p. 1413 - 1418
反应条件
1: 1.) n-BuLi
2: TFA
3: Raney-Ni
View Scheme
参考文献
Campiani, Giuseppe; Kozikowski, Alan P.; Wang, Shaomeng; Ming, Liu; Nacci, Vito; Saxena, Ashima; Doctor, Bhupendra P.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 11 p. 1413 - 1418
反应条件
rhodium (II) acetate; trifluoroacetic acid
1) CH2Cl2, reflux, 10 min, 2) reflux, 15 min; Yield given. Multistep reaction;
参考文献
Copinga, Swier; Dijkstra, Durk; Vries, Jan B. de; Grol, Cor J.; Horn, Alan S.
Recueil des Travaux Chimiques des Pays-Bas, 1993 , vol. 112, # 2 p. 137 - 142
